Background Infections are the most common expected AEs linked to biologic (b) DMARDs in paediatric patients (pts) with juvenile idiopathic arthritis (JIA). Blood concentrations achieved with bDMARDs vary greatly between individual pts. It is not known if higher abatacept (ABA) exposure is linked to higher infection risk in paediatric populations.
Objectives To assess the relationship between the incidence of infection and SC (50–125 mg weekly) and IV (10 mg/kg monthly) ABA exposure in pts with polyarticular-course JIA (pJIA).
Methods Data from the 4 month open-label periods of a Phase III SC ABA study (NCT01844518; weight-tiered ABA: 10–<25 kg [50 mg], 25–<50 kg [87.5 mg],≥50 kg [125 mg]; 219 pts aged 2–17 years) and an IV ABA study (NCT00095173; ABA 10 mg/kg monthly; 184 pts aged 6–17 years) in pts with pJIA were analysed. The association between serum ABA exposure measures (steady-state trough [Cminss], maximum [Cmaxss] and time-averaged [Cavgss] concentrations) estimated by population pharmacokinetic analysis and time to first infection (regardless of seriousness) was assessed. Kaplan–Meier (KM) plots of infection probability versus time to first infection by ABA exposure quartiles were created and log-rank test was performed to test the differences in distribution of time to first infection across exposure quartiles. Box plots of ABA exposure measures over time to Month 4 were generated, stratified by first infection occurrence (yes/no). Data for SC and IV ABA were assessed separately and pooled.
Results Baseline demographic and clinical characteristics were comparable in the SC and IV studies.1 2 Overall, 135/403 pts (33.5%) had ≥1 infection over 4 months: 77/219 (35.2%) with SC ABA and 58/184 (31.5%) with IV ABA. KM plots for pooled SC and IV ABA showed no statistically significant difference in infection probability across four quartiles of ABA Cminss (Fig A; p=0.2317; log-rank test), Cmaxss (p=0.5501) or Cavgss (p=0.3808). Consistent results were seen for individually studied SC and IV ABA Cminss (Fig B, C), Cmaxss and Cavgss (not shown). In addition, there was no difference in median ABA exposure measures by infection occurrence (yes/no) in pooled and separate SC and IV analyses.
Conclusions In pts with pJIA who received SC or IV abatacept, higher relative abatacept exposure was not associated with a higher risk of infections for 4 months.
References  Ruperto N, et al. Lancet2008;372:383–91.
 Lovell D, et al. Arthritis Rheumatol2016;68(Suppl 10), abstract 948.
Disclosure of Interest N. Ruperto Grant/research support from: Bristol-Myers Squibb, Roche, Janssen, Novartis, Pfizer, Sobi, Consultant for: AbbVie, Ablynx, Amgen, AstraZeneca, Baxalta Biosimilars, Biogen Idec, Boehringer Ingelheim, Bristol-Myers Squibb, Celgene, Eli-Lilly, EMD Serono, Gilead Sciences, Janssen, MedImmune, Novartis, Pfizer, R-Pharm, Roche, Sanofi, Servier, Takeda, Speakers bureau: AbbVie, Ablynx, Amgen, AstraZeneca, Baxalta Biosimilars, Biogen Idec, Boehringer Ingelheim, Bristol-Myers Squibb, Celgene, Eli-Lilly, EMD Serono, Gilead Sciences, Janssen, MedImmune, Novartis, Pfizer, R-Pharm, Roche, Sanofi, Servier, Takeda, H. Brunner Consultant for: Novartis, Genentech, Pfizer, UCB, Lilly, Janssen, Ablynx, AbbVie, Bristol-Myers Squibb, EMD Serono, AstraZeneca, Speakers bureau: Genentech, Novartis, N. Tzaribachev: None declared, I. Louw Consultant for: Janssen, Pfizer, Roche, I. Calvo Grant/research support from: Novartis, Speakers bureau: AbbVie, Novartis, Roche, Sobi, G. Horneff Grant/research support from: AbbVie, Bristol-Myers Squibb, Chugai, Pfizer, Janssen/MSD, Novartis, Roche, Consultant for: AbbVie, Bristol-Myers Squibb, Chugai, Pfizer, Janssen/MSD, Novartis, Roche, M. Henrickson: None declared, M. Rama: None declared, M. Fischbach: None declared, T. Miraval: None declared, M. Ally: None declared, X. Li Shareholder of: Bristol-Myers Squibb, Employee of: Bristol-Myers Squibb, R. Wong Shareholder of: Bristol-Myers Squibb, Employee of: Bristol-Myers Squibb, M. Nys Shareholder of: Bristol-Myers Squibb, Employee of: Bristol-Myers Squibb, B. Murthy Shareholder of: Bristol-Myers Squibb, Employee of: Bristol-Myers Squibb, K. Lin Employee of: Cognigen Corporation, a SimulationsPlus company, J. Passarell Employee of: Cognigen Corporation, a SimulationsPlus company, A. Martini Consultant for: AbbVie, Biogen, Boehringer-Ingelheim, Bristol-Myers Squibb, EMD Serono, Janssen, Novartis, Pfizer, R-Pharm, D. Lovell Grant/research support from: National Institutes of Health, NIAMS, Consultant for: AstraZeneca, Bristol-Myers Squibb, AbbVie, Pfizer, Roche, Novartis, UCB, Forest Research Institute, Horizon, Johnson and Johnson, Biogen, Takeda, Genentech, GlaxoSmithKline, Boehringer Ingelheim, Celgene, Janssen, Speakers bureau: Genentech
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