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FRI0718-HPR Are pain, activity limitations and quality of life associated with objectively measured physical activity in patients with end-stage osteoarthritis of the hip or knee?
  1. C. Leichtenberg1,
  2. F. van Tol1,
  3. T. Krom1,
  4. C. Tilbury1,
  5. H. Horemans2,
  6. H. Bussmann2,
  7. R. Nelissen1,
  8. M. Gademan1,3,
  9. T. Vliet Vlieland1,
  10. on behalf of the LOAS Study group1
  1. 1Department of Orthopaedics, LUMC, Leiden
  2. 2Department of Rehabilitation, ErasmusMC, Rotterdam
  3. 3Department of Epidemiology, LUMC, Leiden, Netherlands


Background: Hip and knee osteoarthritis (OA) are a major cause of disability, yet relatively little is known on the relationship between OA and the total amount of physical activity.

Objectives: We investigated if OA-associated pain, functional disability and quality of life (QoL) are associated with objectively measured physical activity in patients with end-stage hip/ knee

Methods: Preoperative data from the Longitudinal Leiden Orthopaedics Outcomes of Osteoarthritis Study (LOAS) were used. All patients were scheduled for primary total hip or knee arthroplasty. Patients wore an accelerometer (Activ8 Remedy Distribution Ltd) which assessed levels of physical activity (LPA) in activity counts and %time spent on physical activity (%PA, i.e. time spent on walking, cycling or running) and sedentary behaviour (%SB, i.e. time spent in lying/sitting). Pain, functional disability and health related QoL were assessed with the Hip Disability and Knee Injury Osteoarthritis Outcome Scores (HOOS/KOOS) and Short-Form 12 (SF12). Multivariate linear regressions models adjusted for confounding were conducted. The physical activity outcomes were transformed to Z-scores.

Results: 9 hip OA and 48 knee OA patients were included. When awake, mean LPA was 18.787± 7.247 for hip OA patients and 21.193± 6.164 for knee OA patients. In hip OA patients %PA was on average 14±6.4, while %SB was 66±10.5. In knee OA patients these percentages were 15±5.0 and 68±8.7, respectively. In hip OA, the HOOS-QoL and SF12-PCS were positively associated with more LPA, (β0.028; 95%CI:0.007 – 0.048, β0.041; 95%CI:0.010 – 0.071) and better SF12-PCS scores also with PA (β 0.040, 95%CI:0.007 – 0.073). No other associations were found.

Conclusions: Whereas QoL was associated with physical activity in end-stage hip OA patients, no associations between pain or functional disability and physical activity were observed in either hip or knee OA.

Acknowledgements: This study was supported by the Dutch Arthritis Association [grant number LLP13].

Disclosure of Interest: None declared

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