Background Several studies have shown the effect of platelet rich plasma (PRP) on knee osteoarthritis. Most of these studies have focused on subjective and clinical symptoms effect of PRP and fewer papers have studied its objective effect on cartilage. MRI is the gold standard imaging for cartilage lesion.
Objectives In this study, we investigated the effect of PRP on cartilage characteristics by special MRI sequencing.
Methods In the double blind randomised clinical trial, patients with grade1, 2 and 3 of osteoarthritis were included in this study. All of the knees divided to groups randomly and exercise was prescribed for all of knees. Beside, PRP was injected 2 courses with 4 weeks interval in PRP group. For all of patients before and 6 months after treatment VAS (visual analogue scale) and WOMAC (Western Ontario and McMaster Universities Arthritis Index) were fulfilled and MRI was performed. Sequencings of MRI were PD fat saturated (coronal and sagittal) and transverse TRUFISP 3D. Imaging was scored according to 4 cartilage’s characteristics including, Patellofemoral cartilage volume, Subarticular bone marrow abnormality, Medial and lateral meniscal disintegrity and Synovitis.
Results 23 knees in case group and 23 knees in control group were studied. All of patients were female with mean age 57.57±5.9 years old and mean BMI 28.49±3.24 (Kg/m2).52% of knees had grade 2 of osteoarthritis. Mean total WOMAC and VAS changes before and after treatment in control group were 11.61±1.3 and 8.5±1.1 respectively. In PRP group, mean total of WOMAC and VAS changes showed better improvement with 20±3.2 and 12.3±1.6 respectively (P-Value<0.05). In PRP group all of the radiologic variables except subarticular bone marrow abnormality had significantly improvement (P-Value<0.05). In comparison between 2 groups, Patellofemoral cartilage volume and synovitis had significantly changes in PRP group (P-Value<0.05).
Conclusions In this study, in addition to the effect of PRP on VAS and WOMAC, there is effect on radiologic characteristics (Patellofemoral cartilage volume and synovitis) significantly. For more evaluation, Study with more sample size is recommended.
References  Raeissadat SA, Babaee M, Rayegani SM, Hashemi Z, Hamidieh AA, Mojgani P, et al. An overview of platelet products (PRP, PRGF, PRF, etc.) in the Iranian studies. Future science OA. 2017;3(4):FSO231.
 Raeissadat SA, Rayegani SM, Ahangar AG, Abadi PH, Mojgani P, Ahangar OG. Efficacy of Intra-articular Injection of a Newly Developed Plasma Rich in Growth Factor (PRGF) Versus Hyaluronic Acid on Pain and Function of Patients with Knee Osteoarthritis: A Single-Blinded Randomized Clinical Trial. Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders. 2017;10:1179544117733452.
 Raeissadat SA, Rayegani SM, Hassanabadi H, Fathi M, Ghorbani E, Babaee M, et al. Knee osteoarthritis injection choices: platelet-rich plasma (PRP) versus hyaluronic acid (a one-year randomized clinical trial). Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders. 2015;8:CMAMD. S17894.
 Raeissadat SA, Rayegani SM, Moridnia M, Dehgolan SR. AB1246-HPR Intra articular ozone or hyaluronic acid injection: which one is superior in patients with knee osteoarthritis? a 6-month randomized clinical trial. BMJ Publishing Group Ltd; 2017.
Disclosure of Interest None declared
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