Background Acute anterior uveitis is the most common extra-articular manifestation of spondyloarthritis (SpA). The ocular inflammation in SpA is restricted to the uvea, usually unilateral and in some cases may precede the clinical characteristics of SpA.

Objectives The aim of this study is to analyse if the presence of uveitis is associated with a diferent clinical manifestation, laboratorial, radiological and therapetiuc among spondyloarthritis patients.

Methods This was an observational retrospective study with 153 patients with spondyloarthritis attended in the period from 1997 to 2017 in Florianopolis, Brazil. It was analysed demografical, laboratorial, clinical and therapeutic data in spondyloarthritis patients with or without uveitis.

Results 26,8% of the patients with spondyloarthritis presented uveitis. The presence of complications was rare, with cataract occurring in only four patients and glaucoma in two of them. A higher frequency of acute anterior uveitis in males (p=0.06) was observed in patients with a family history (p=0.19) and HLA-B27 positive (p=0.14). Patients with spondyloarthritis and uveitis more frequently used anti-TNF (p=0.04) and presented sacroiliitis on imaging tests (p=0.02). There was no association between uveitis and cardiovascular (p=0.44), cutaneous (p=0.13) or gastrointestinal involvement (p=0.10).

Conclusions Uveitis in patients with spondylarthritis is common, predominantly in males and more frequently, in HLA-B27 positive patients. Ocular manifestation in spondyloarthritis has a low degree of complication when compared to uveitis from other etiologies. The use of immunobiological agents such as anti-TNF is common in patients with uveitis.

References [1] Stolwijk C, van Tubergen A, Castillo-Ortiz JD, Boonen A. Prevalence of extra-articular manifestations in patients with ankylosing spondylitis: a systematic review and meta-analysis. Ann Rheum Dis. 2013;74(1):65–73

[2] Rosenbaum JT. New developments in uveitis associated with HLA B27. Curr Opin Rheumatol. 2017;29(4):298–303.

[3] Pasadhika S, Rosenbaum JT. Update on the use of systemic biologic agents in the treatment of noninfectious uveitis. Biol Targets Ther. 2014;8:67–81.

[4] Khan MA, Haroon M, Rosenbaum JT. Acute Anterior Uveitis and Spondyloarthritis: More Than Meets the Eye. Curr Rheumatol Rep. 2015;17(9).

[5] Cantini F, Nannini C, Cassarà E, Kaloudi O, Niccoli L, Cassara E, et al. Uveitis in Spondyloarthritis: An Overview. J Rheumatol Suppl. 2015;93:27–9.

[6] Rosenbaum JT. Uveitis in spondyloarthritis including psoriatic arthritis, ankylosing spondylitis, and inflammatory bowel disease. Clin Rheumatol. 2015;34(6):999–1002.

Disclosure of Interest None declared