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AB0618 Prevalence of hypovitaminosis d in adults with systemic lupus erythematosus and the relationship with sledai 2k in patients treated in two rheumatology services, bogota 2017
  1. R.A. Guzman Moreno,
  2. L.G. Piñeros,
  3. J. Garcia,
  4. L.M. Pombo,
  5. A. Teheran,
  6. J. Bustillo,
  7. K.A. Guzman Moreno,
  8. V. Cadavid,
  9. M.C. Mejia
  1. Inmuno Reumatologia and Internal Medicine, IDEARG. Fundación Universitaria Juan N Corpas, Bogota, Colombia


Background Vitamin D is a steroid hormone with pleiotropic effects on physiological processes. Among others, immune system regulation and their analogues prevent symptom development of autoimmune diseases such as SLE. A previous research in a colombian clinic found a prevalence of hipovitaminosis D of 87% in healthy population, but hypovitaminosis D is higher in SLE patients than healthy controls.

Objectives To establish the prevalence of hypovitaminosis D in patients with SLE and relationship with SLEDAI – 2K.

Methods A cross sectional study was carried out. 80 medical records with a diagnoses of SLE o CIE-10 M30-M36 were identified and we included patients>18 years of age who meet at least 4 of the 11 criteria to diagnoses of SLE for medical record. The analysis included means, DS and Kruskall Wallis with p-value<0.05.

Results The majority of patients are women (94%), with an average age of 39.9 years, married (41%), with secondary education (56.7%) and different occupations. It was found that the patients with higher activity, had lower vitamin D levels. Additionally, if the patient had lupus nephritis, vitamin D levels decreased even more.

Conclusions Patients with active systemic lupus Erythematosus, (SLE) have hypovitaminosis D more frequently and we noticed that patients with renal involvement have the lowest levels of vitamin D, which justifies a later analysis.

References [1] American College of Rheumatology. Guidelines for referral and management of systemic lupus erythematosus in adults. Arthritis Rheum. 1999Sep;42(9):1785–96.

[2] Simioni J, Heimovski F, Skare T. On lupus, vitamin D and leukopenia. 2016;56(3):206–211.

[3] Guzman R.A, Piñeros L.G, Theran A, Flechas J, Mejía M. AB0795 Hypovitaminosis D and Calcium Intake of Adult Population in Bogota (DICAVITD). Ann Rheum Dis2016;75:1175–1176.

[4] Alele J., et al. Autoimmun Rev2010;9:137–39.

[5] Dall, era M., et al. in Kelley&Firestein,s Textbook of Rheumatology. 10th Ed, Elsevier; Philadelphia 2017; 1368–89.

Disclosure of Interest None declared

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