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AB0582 Soluble triggering receptor expressed on myeloid cells-1 (STREM-1) and adrenomedulin are elevated in patients with systemic lupus erythematosus
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  1. I. Jeremic1,
  2. N. Stojanovic1,
  3. Z. Stanojevic2,
  4. B. Jovanovic3,
  5. J. Tosic2,
  6. S. Vidicevic2,
  7. A. Isakovic2
  1. 1Institute of Rheumatology, Belgrade
  2. 2Institute of Biochemistry, Belgrade
  3. 3Clinical Centre of Serbia, Belgrade, Serbia

Abstract

Background Adrenomedulin is a peptide firstly isolated from human phaeochromocytoma with vasodilatory effects. Secretion of adrenomedulin is modified by inflammatory cytokines and it may be important as a suppressor of lupus nephritis activity. Triggering receptor expressed on myeloid cells-1 (TREM) is a member of immunoglobulin superfamily clearly elevated in inflammatory conditions. Some subgroups of patients with systemic lupus erythematosus-SLE may have especially elevated levels of s-TREM.

Objectives The aim of this study was to examine adrenomedulin and s-TREM levels in patients with SLE and healthy controls and to assess their relation with SLE disease activity index-SLEDAI

Methods Serum samples from 50 SEL patients and 40 healthy blood donors were analysed. Serum levels of adrenomedulin, s-TREM, complement components C3 and C3, and anti-dsDNA antibodies were measured

Results Patients with SLE had higher adrenomedulin (9.8±4.5 vs. 15.3±7.2 pg/mL, p<0.05) and s-TREM (11.7±4.1 vs. 20.3±13.1 pg/mL) (p<0.05) levels. s-TREM showed correlation with anti-dsDNA antibodies (ρ=0.405, p<0.05) and SLEDAI score (ρ=0.386, p<0.001). In multivariate analysis s-TREM did not appear as an independent predictor of SLEDAI score, while only anti-dsDNA antibodies were significant in multivariate analysis.

Conclusions Increased adrenomedulin and s-TREM are found in lupus sera. Despite of correlation with SLEDAI score, s-TREM is not better then anti-dsDNA antibodies as a predictor of SLE disease activity.

Disclosure of Interest None declared

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