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SAT0687 Silicone breast implants and the risk of autoimmune diseases: real world analysis
  1. A. Watad1,
  2. V. Rosenberg2,
  3. S. Tiosano1,
  4. J.W. Cohen Tervaert3,
  5. Y. Yavne4,
  6. Y. Shoenfeld5,
  7. V. Shalev6,
  8. G. Chodick2,
  9. H. Amital4
  1. 1Internal Medicine B, Sheba Medical Center
  2. 2Epidemiology, Maccabi Healthcare Services, Tel-Aviv, Israel
  3. 3Medicine and Immunology, Maastricht University, Maastricht, Netherlands
  4. 4Sheba Medical Center, Tel-Aviv, Israel
  5. 5The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center
  6. 6Maccabi Healthcare Services, Tel-Aviv, Israel


Background Previous reports have suggested an association between silicone breast implants (SBIs) and connective tissue disorders. However, several epidemiological studies have produced inconsistent results.

Objectives To evaluate the association between SBIs and the most clinically relevant auto-immune diseases (ADs) using a large, population based database.

Methods In this cross-sectional study, we used the computerised databases of Maccabi Healthcare Services (MHS) which include up to 20 years of data on 2 million members. Women with SBIs were identified by procedure and diagnosis codes, clinical breast examinations and mammography referrals. ADs were identified using the International Classification of Diseases 9th revision (ICD-9) codes. SBIs-free women were matched by age group and socio-economic status (SES) in a ratio of 1:4. Multivariable logistic regression and Cox’s proportional hazards models were performed.

Results We included 24,651 SBI recipients and 98 604 matched SBIs free women in our study. The association between SBIs and AD was significant (p<0.05) (adjusted OR 1.21, 95% CI 1.17–1.26). The strongest association with SBIs (OR >1.5, p<0.001) was recorded for systemic sclerosis (SSc) and sarcoidosis (OR of 1.99 and 1.67, respectively). Similar results were calculated when analysis was limited to cancer free women. Multivariable Cox regression model yielded a HR of 1.45 (95% CI 1.21–1.73) for being diagnosed with at least one AD in women with SBI compared to those without.

Abstract SAT0687 – Figure 1

Kaplan-Meier plot for diagnosis with an auto-immune among SBI recipients and SBI-free women (n=8906). P-value from log rank test <0.001. Note: SB=silicone breast implants

Conclusions SBIs seems to be associated with higher likelihood of auto-immune disease diagnosis.

Acknowledgements None

Disclosure of Interest None declared

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