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SAT0303 Pain mechanisms and ultrasonic inflammatory activity as prognostic factors in patients with psoriatic arthritis: results of a danish prospective, exploratory cohort study
  1. P. Højgaard1,2,
  2. K. Ellegaard1,
  3. S.M. Nielsen1,
  4. R. Christensen1,
  5. J. Guldberg-Møller1,
  6. C. Ballegaard1,2,
  7. L. Dreyer1,2,
  8. P. Mease3,
  9. M. de Wit4,
  10. L. Skov5,
  11. B. Glintborg2,6,
  12. H. Bliddal1,
  13. E.M. Bartels1,
  14. K. Amris1,
  15. L.E. Kristensen1
  1. 1The Parker Institute, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark
  2. 2Center for Rheumatology and Spine diseases, Rigshospitalet Gentofte, Hellerup, Denmark
  3. 3Swedish Medical Center, University of Washington, Seattle, USA
  4. 4Department of Medical Humanities, Vrije University, Amsterdam, Netherlands
  5. 5Department of Dermatology and Allergology, Herlev and Gentofte Hospital, Hellerup, Denmark
  6. 6Center for Arthritis Research COPECARE, Rigshospitalet Glostrup, Glostrup, Denmark

Abstract

Background Pain is a major concern for patients with psoriatic arthritis (PsA) in spite of treatment with biologic/conventional disease modifying drugs (b/csDMARDS). Studies on the prognostic role of pain mechanisms in PsA, are scarce.

Objectives To investigate the presence of widespread non-arthritic pain (WP) in patients with PsA, and determine its relation to patient-reported, clinical- and ultrasound (US) disease measures, as well as to achievement of 4 months response to b/csDMARD therapy. Secondly, to study if US Colour Doppler activity (CD) at baseline is associated to treatment response.

Methods A prospective cohort study was performed following a protocol.1Patients initiating b/csDMARDs for PsA were recruited from rheumatology clinics in Copenhagen. Clinical- and US examinations and patient-reported outcomes (PROs) were performed at baseline and after 4 months. WP was defined as a Widespread Pain Index≥4, and pain in ≥4/5 regions. CD activity in selected joints, entheses and tendons (73 projections) was summed. Response was assessed by American College of Rheumatology 20% (ACR20), Disease Activity in Psoriatic Arthritis 50% (DAPSA 50) and Minimal Disease Activity (MDA). Main response analyses were based on intention to treat with non-responder imputation, and consisted of logistic regressions adjusting for gender and age.

Results Of 123 screened patients, 69 were included. Of these, 24 (35%) fulfilled the WP definition. At baseline (Table), WP was associated with worse PROs and composite scores, while CD activity and clinical measures were similar to those without WP. WP profile was significantly related to achievement of MDA at follow-up but not to other response criteria (table 1). Presence of CD activity at baseline was not significantly associated to 4 months response by any criteria, e.g. 19%/31% with CD=0/CD >0, reached ACR20, (p=0.262).

Abstract SAT0303 – Table 1

Baseline characteristics

Conclusions WP was present in 1/3 of patients, and associated with worse PROs, composite measures, and failure to achieve MDA at follow-up. Neither WP nor CD at baseline was related to other response measures.

Reference Højgaardet al. BMJ Open2006;6. doi:10.1136/bmjopen-2015-010650

Acknowledgements Thanks to: The Oak foundation, Danish Rheumatism Association, Centre for Rheumatology Gentofte Hospital.

Disclosure of Interest None declared

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