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We complement the authors on their systematic review and meta-analysis on metabolic and cardiovascular (CV) benefits of hydroxychloroquine (HCQ).1 The authors have restricted the meta-analysis to studies comparing HCQ users versus non-users in rheumatoid arthritis (RA). This criterion has precluded the inclusion of many studies where metabolic and CV benefits of HCQ have been reported. We would like to highlight these to add to the significant benefits of this molecule, thus widening the evidence base.
Authors did not include studies comparing HCQ with other disease-modifying antirheumatic drugs (DMARDs) and biologicals. In a study cohort of 13 905 participants, majority of …
Competing interests Authors are involved in research studies on hydroxychloroquine.
Provenance and peer review Not commissioned; internally peer reviewed.