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Handling editor Josef S Smolen
Contributors GD is responsible for study design, data collection, data analysis, and editing and approval of manuscript. TLM and JBM are responsible for data collection, and editing and approval of manuscript. AKM is responsible for study design, data analysis and editing and approval of manuscript. RA, KO, MD, CT and ALH responsible for study design and editing and approval of manuscript.
Funding This study was funded by Manchester: Integrating Medicine and Innovative Technology.
Competing interests None declared.
Patient consent Obtained.
Ethics approval West Midlands (Edgbaston) Research Ethics Committee (reference 14/WM/1272).
Provenance and peer review Not commissioned; externally peer reviewed.
Data sharing statement No additional unpublished data from the study have been made available.