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We thank Dr Aslam for his thoughtful comments1 regarding our article entitled ‘The value of 18F-FDG-PET/CT in identifying the cause of fever of unknown origin (FUO) and inflammation of unknown origin (IUO): data from a prospective study’.2 Dr Aslam mentions that due to increasing prevalence of obesity in the industrialised world, average C reactive protein levels rise merely because of the increased volume of adipose tissue in the body, even in the absence of concomitant inflammatory disease. This association has been supported by epidemiological studies3 and is likely based on the proinflammatory role of …
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