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Methyl-CpG-binding protein 2 mediates antifibrotic effects in scleroderma fibroblasts
  1. Ye He1,2,
  2. Pei-Suen Tsou1,
  3. Dinesh Khanna1,
  4. Amr H Sawalha1,3
  1. 1 Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
  2. 2 Department of Dermatology, The Second Xiangya Hospital, Central South University, Changsha, China
  3. 3 Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA
  1. Correspondence to Dr Amr H Sawalha, Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA; asawalha{at}umich.edu

Footnotes

  • Handling editor Josef S Smolen

  • Contributors All authors made substantial contributions to the conception or design of the work; or the acquisition, analysis or interpretation of data for the work; drafting the work or revising it critically for important intellectual content; final approval of the version to be published; and agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

  • Funding This work was supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health grant number R01AI097134 to Dr Sawalha. Dr Khanna is supported by NIH (National Institute of Arthritis and Musculoskeletal and Skin Diseases) grant number K24AR063120.

  • Competing interests None declared.

  • Patient consent Not required.

  • Ethics approval This study was approved by the institutional review board of the University of Michigan.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Correction notice This article has been corrected since it published Online First. The subtitle ’Gene knockdown experiments' has been updated.

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Footnotes

  • Handling editor Josef S Smolen

  • Contributors All authors made substantial contributions to the conception or design of the work; or the acquisition, analysis or interpretation of data for the work; drafting the work or revising it critically for important intellectual content; final approval of the version to be published; and agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

  • Funding This work was supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health grant number R01AI097134 to Dr Sawalha. Dr Khanna is supported by NIH (National Institute of Arthritis and Musculoskeletal and Skin Diseases) grant number K24AR063120.

  • Competing interests None declared.

  • Patient consent Not required.

  • Ethics approval This study was approved by the institutional review board of the University of Michigan.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Correction notice This article has been corrected since it published Online First. The subtitle ’Gene knockdown experiments' has been updated.

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