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- systemic vasculitis
- autoimmune diseases
- disease activity
- granulomatosis with polyangiitis
- sjoegren’s syndrome
Peripheral nerve biopsy remains the gold standard for diagnosing vasculitic neuropathy (VN).1 This procedure is invasive, of limited sensitivity and not always feasible.2 A biomarker indicating acute axonal loss in patients with systemic vasculitis would allow rapid screening and adjustments of diagnostic or treatment strategies, potentially improving clinical outcome.3
Neurofilaments are structural proteins specific to neurons that are released into blood and cerebrospinal fluid following neuronal damage. They have been suggested as a biomarker in various neurological diseases, mainly affecting the central nervous system.4–6 In patients with multiple sclerosis, serum neurofilament light chain (sNfL) levels correlated with MRI and clinical disease activity/severity, were lower in patients under treatment and showed potential to predict future disease activity and disability.5
In this retrospective study we aimed to test whether sNfL could serve as a marker of vasculitic damage of peripheral nerves and/or disease activity in patients with VN. Patients were recruited from our prospective local ethical board-approved vasculitis …
Contributors Design or conceptualisation of the study: AB, ToD, JK, ThD. Analysis or interpretation of the data: AB, TM, CB, IH, CTB, ToD, JK, ThD. Drafting or revising the manuscript for intellectual content: AB, TM, CB, IH, CTB, ToD, JK, ThD.
Funding AB received grants from the Freiwillige Akademische Gesellschaft, Switzerland, and from the Gottfried and Julia BangerterRhyner Foundation, Switzerland.
Patient consent Obtained.
Provenance and peer review Not commissioned; externally peer reviewed.
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