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Active joint inflammation is a key feature in rheumatoid arthritis (RA). Treatment guidelines for RA,1 including ‘Treat-to-Target’ strategies,2 stress the importance of abrogation of inflammation. MRI clearly demonstrates bone marrow oedema lesions (BMEL) as a sign of inflammation.3 Dual-energy CT (DECT) scanners could provide a new approach to visualise BME.4–7 We investigated if DECT could visualise BME of the hand and wrist in patients with active RA, with MRI-proven BME as a gold standard.
Institutional review board approval was obtained. Twenty consecutive patients with active clinical synovitis of a metacarpophalangeal, proximal interphalangeal or wrist joint provided written informed consent and were included; 9 men and 11 women with a mean age of 60.7 (±10.3) years. Thirteen patients were ACPA positive and 8 were ACPA and RF positive; mean tender joint count and swollen joint count were both 5.9. Mean DAS28 was 4.37 (±1.4). The mean disease duration was 6.6 (±6.1) years. Seventeen patients were treated with conventional disease-modifying antirheumatic drugs, 7 were also treated with biologicals.
DECT was performed on a dual-source CT, data were post-processed with SyngioVia ‘Bone Marrow Oedema’ application (see the online supplementary text). Images were presented as colour-coded maps. …
DE and PJ contributed equally.
Handling editor Josef S Smolen
Contributors LJ: had full access to all of the data in this study and takes responsibility for the integrity of the data and accuracy of the data analysis. LJ, IDK, KV, FVDB, DE and PJ: study design. LJ, NH, FVDB, PC, EO, DE and PJ: acquisition of data. LJ and NH: analysis of data. LJ: statistical analysis. All authors: manuscript preparation, reviewed and approved the manuscript.
Funding This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent Obtained.
Ethics approval Institutional Review Board approval was obtained.
Provenance and peer review Not commissioned; externally peer reviewed.
Data sharing statement No additional data are available from this study.
Correction notice This article has been corrected since it published Online First. The shared contribution statement for Dirk Elewaut and Peggy Jacques has been added and the affiliations have been added to authors Filip Van den Bosch, Philippe Carron and Peggy Jacques.
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