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  • How are enthesitis, dactylitis and nail involvement measured and reported in recent clinical trials of psoriatic arthritis? A systematic literature review

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Letter
How are enthesitis, dactylitis and nail involvement measured and reported in recent clinical trials of psoriatic arthritis? A systematic literature review
  1. Sofia Ramiro1,
  2. Josef S Smolen2,3,
  3. Robert Landewé4,
  4. Désirée van der Heijde1,
  5. Laure Gossec5
  1. 1 Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
  2. 2 Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria
  3. 3 Department of Medicine, Hietzing Hospital, Vienna, Austria
  4. 4 Department of Clinical Immunology and Rheumatology, Amsterdam Rheumatology Center, Amsterdam and Zuyderland Hospital, Heerlen, The Netherlands
  5. 5 Department of Rheumatology, Sorbonne Universités, UPMC Univ Paris 06, Institut Pierre Louis d’Epidémiologie et de Santé Publique, GRC-UPMC 08 (EEMOIS); AP-HP, Pitié Salpêtrière Hospital, Paris, France
  1. Correspondence to Dr Sofia Ramiro, Department of Rheumatology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; sofiaramiro{at}gmail.com

https://doi.org/10.1136/annrheumdis-2017-211447

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    While enthesitis, dactylitis and nail involvement are recognised as important outcomes of psoriatic arthritis (PsA) in the core set of domains in PsA,1 2 it is still unclear how these outcomes should best be measured.1 2 We systematically reviewed the instruments and the cut-offs used to report state or improvement, for enthesitis, dactylitis and nail involvement in recent randomised controlled trials (RCTs) in PsA.

    A systematic literature review of RCTs on any pharmacological intervention in patients with PsA was conducted to inform the European League Against Rheumatism (EULAR) recommendations for the management of PsA, by searching Medline, Embase and Cochrane datasets for the period 2010–2015.3 4 Only published papers and only results of the placebo-controlled phases were analysed. The presence and type of all outcome measures reflecting enthesitis, …

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    Footnotes

    • Contributors All authors contributed to this letter and approved its last version.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.