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We appreciate the comments by Jiang et al 1 on our study showing that IL-38 overexpression has anti-inflammatory effects in experimental arthritis presumably through decreased production of proinflammatory cytokines by macrophages.2 Jiang et al point out that the Iba1 marker used in our immunohistochemistry analysis is also expressed by dendritic cells (DCs) and that IL-23, whose expression is reduced by IL-38, is also highly expressed by DCs. Therefore, IL-38 could target DCs in addition to macrophages.
Ionised calcium-binding adaptor molecule 1 (Iba1) also known as allograft inflammatory factor 1 (AIF-1) is widely accepted as a pan-macrophage marker expressed in …
Competing interests None declared.
Provenance and peer review Commissioned; internally peer reviewed.
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