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The effects of inflammatory disease activity (DA) on radiographic progression in patients with axial spondyloarthritis (axSpA) are worse in men and smokers, but an explanation for this is lacking.1 Recently, we have found a relationship between inflammatory lesions in the sacroiliac joints (SIJs) detected by MRI and clinical DA measures in male patients, which was absent in female patients.2 Here, we investigate whether this gender-specific association between MRI-lesions and clinical DA extends to the spine.
The objectives of this study were: (i) to explore the relationship between inflammatory lesions of the spine on MRI and DA in patients with axSpA; (ii) to investigate if such a relationship is gender specific and (iii) to explore the influence of other patient-related factors on the relationship between MRI of the spine and DA.
Two-year follow-up data from 164 patients fulfilling Assessment of SpondyloArthritis international Society (ASAS) axSpA criteria in the DEvenir des Spondylarthopathies Indifférenciées Récentes (DESIR) cohort with at least two spine MRIs available during this period were analysed.3 ,4
The relationship between MRI-spine and DA (Ankylosing Spondylitis Disease Activity Score (ASDAS), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), patient’s global DA, night pain, C reactive protein (CRP) and erythrocyte sedimentation rate (ESR)) was analysed by generalised estimating equations (GEEs) on absolute MRI-spine scores (Berlin …
Contributors VN-C, SR, RL and DvdH designed the study. VN-C and SR performed the statistical analyses. RL, MD and DvdH critically interpreted the results. VN-C wrote the first draft of the manuscript. All authors reviewed the draft version and approved the final manuscript.
Funding This project was supported by an unrestricted grant from Pfizer.
Competing interests None declared.
Patient consent Obtained.
Ethics approval This study is conducted under the umbrella of the French Society of Rheumatology and Institut National de la Santé et de la Recherche Médicale (INSERM).
Provenance and peer review Not commissioned; externally peer reviewed.
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