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Optical coherence tomography as a method for quantitative skin evaluation in systemic sclerosis
  1. Natália Sotero Machado Pires1,
  2. Andréa Tavares Dantas2,
  3. Angela Luzia Branco Pinto Duarte2,
  4. Marcello Magri Amaral3,
  5. Luana Osório Fernandes1,
  6. Tereza Januária Costa Dias1,
  7. Luciana Santos Afonso de Melo4,
  8. Anderson Stevens Leônidas Gomes1,4
  1. 1Graduate Program in Dentistry, Federal University of Pernambuco, Recife, Pernambuco, Brazil
  2. 2Department of Rheumatology, Federal University of Pernambuco, Recife, Pernambuco, Brazil
  3. 3Laboratory of Biophotonics, Center for Lasers and Applications, IPEN—CNEN/SP, São Paulo, São Paulo, Brazil
  4. 4Department of Physics, Federal University of Pernambuco, Recife, Pernambuco, Brazil
  1. Correspondence to Dr Andréa Tavares Dantas; Hospital das Clínicas, Rua Prof. Moraes Rego, Recife, PE50740-900, Brazil; andreatdantas{at}

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Improved, non-invasive techniques for the diagnosis, classification and monitoring of patients with systemic sclerosis (SSc) are needed. One potential technique for quantifying the extent of cutaneous sclerosis in these patients is optical coherence tomography (OCT).1 ,2 Recently, Abignano et al3 suggested the use of OCT as a feasible and reliable technique to evaluate skin fibrosis in SSc. Based on that initial work, the aim of this study was to evaluate OCT images and compare the findings with the modified Rodnan skin score (mRSS) in patients with SSc.

Thirty-three Brazilian patients with SSc (28 women; mean age 46.1 years; range 19–71 years) were recruited and fulfilled criteria for SSc proposed by American College of Rheumatology (ACR), 19804 or ACR/European League Against Rheumatism, 2013.5 Patients were classified into limited SSc (n=18) and diffuse SSc (n=15) groups. The mean disease duration was 9.7 years (median 8 years, range 2–26 months). Thirty-five healthy control (HC) (28 women, …

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  • Contributors NSMP contributed the collection of images with OCT, the project plan, data analysis and manuscript writing. ATD contributed to the clinical appointments, project plan, statistical analysis and manuscript writing. ALBPD contributed with the project plan and manuscript writing. MMA contributed with the all computational analysis using Matlab. LOF contributed with the project plan and data analysis. TJCD and LSAM contributed to the collection of OCT images. ASLG coordinated the study, as well as reviewed the data and the manuscript writing.

  • Competing interests None declared.

  • Ethics approval CEP-CCS-UFPE.

  • Provenance and peer review Not commissioned; externally peer reviewed.