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Simultaneous inhibition of α4/β7 integrin and tumour necrosis factor-α in concomitant spondyloarthritis and inflammatory bowel disease
  1. Nicolas Richard1,2,
  2. Elizabeth M Hazel2,
  3. Nigil Haroon1,
  4. Robert D Inman1
  1. 1 Division of Rheumatology, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada
  2. 2 McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada
  1. Correspondence to Dr. Nicolas Richard, Division of Rheumatology, University Health Network, Toronto Western Hospital, Toronto, ON M5T 2S8, Canada; nicolas.richard2{at}

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We read with interest the article by Varkas et al 1 suggesting a temporal association between the initiation of vedolizumab (VDZ) for inflammatory bowel disease (IBD) and induction or worsening of spondyloarthritis (SpA). This suggests that in patients with IBD, there may be limited efficacy of α4/β7 integrin blockade for management of extraintestinal manifestations, particularly for arthritis and sacroiliitis.2 3 Treatment of SpA in subjects on VDZ for associated IBD is highly challenging for the treating physician. We describe below two patients who were treated with a combination treatment of VDZ and certolizumab pegol (CZP) (table 1).

Table 1

Patient characteristics, treatment and outcome of subjects treated with VDZ and CZP combination therapy

Patient 1 is a 24 year-old man diagnosed with juvenile-onset SpA in 2008 and Crohn’s disease (CD) in 2011. Sequential treatments with numerous tumour necrosis factor (TNF)-α inhibitors were associated with loss of efficacy or intolerance. In 2014, initiation of CZP was able to control articular symptoms. During follow-up, he developed uncontrolled disease activity of his CD, and in 2016 it was decided to add VDZ to the CZP treatment. Excellent responses of both gastrointestinal and musculoskeletal symptoms were noted. After 10 months of ongoing combination therapy, the patient is still without any symptoms of either IBD or SpA. No adverse events were reported.

Patient 2 is a 48 year-old woman diagnosed with ulcerative colitis (UC) in 2012. After inadequate response to numerous TNF-α inhibitors, she was initiated on VDZ. Despite good clinical and endoscopic response of her colitis, she developed inflammatory back pain, peripheral arthritis and enthesitis 5 months following the initiation of VDZ. A pelvic MRI confirmed bilateral sacroiliitis. CZP was initiated in lieu of VDZ to provide adequate control of the arthritis. Nine months after the last infusion of VDZ, the patient presented with a flare of UC. It was then decided to reinitiate VDZ in addition to CZP. After the fourth infusion of VDZ, recurrence in the symptoms of arthritis was noted, and it was decided to discontinue CZP given its loss of efficacy. No adverse events were reported neither during the time of combination therapy nor following its cessation.

In spite of a relatively short follow-up, it is reassuring that no serious adverse events or infectious complications were recorded in our patients. Sustained remission was observed in patient 1, whereas recurrence of arthritis was observed in patient 2. Our report suggests that combination of VDZ and TNF-α could be considered in the therapeutic armamentarium for patients with SpA and IBD. Previous reports similarly showed no increased safety signals4–6; however, larger studies are needed in order to assess the outcomes of simultaneous inhibition of α4/β7 integrin and TNF-α.



  • Contributors All coauthors have contributed to this letter and agree with its content.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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