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We thank Lee and Song1 for their interest in our paper2 that found that compared with non-use, urate-lowering therapy (ULT) use was not associated with increased risk of dementia in adults aged 65 years or older.
We agree with Lee and Song that all observational studies have potential residual confounding related to study design, including our study and the observational studies they listed. Similar to our study, the two studies that Lee and Song have mentioned also did not adjust for serum urate3 4 putting them at the same risk for …
Competing interests None declared.
Provenance and peer review Commissioned; internally peer reviewed.
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