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Response to: ‘Use of urate-lowering therapies is not associated with an increase in the risk of incident dementia in older adults’ by Lee and Song
  1. Jasvinder A Singh1,2,3,
  2. John Cleveland2
  1. 1 Medicine Service, VA Medical Center, Birmingham, Alabama, USA
  2. 2 Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
  3. 3 Division of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA
  1. Correspondence to Dr Jasvinder A Singh, Department of Medicine, University of Alabama, Birmingham, AL 35294, USA;{at}

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We thank Lee and Song1 for their interest in our paper2 that found that compared with non-use, urate-lowering therapy (ULT) use was not associated with increased risk of dementia in adults aged 65 years or older.

We agree with Lee and Song that all observational studies have potential residual confounding related to study design, including our study and the observational studies they listed. Similar to our study, the two studies that Lee and Song have mentioned also did not adjust for serum urate3 4 putting them at the same risk for …

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  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.

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