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We have read the recent paper of l‘Ami et al titled ‘Successful reduction of overexposure in patients with rheumatoid arthritis with high serum adalimumab concentrations: an open-label, non-inferiority, randomised clinical trial’ with interest.1 The topic of dose tapering is an important one and we welcome all research efforts in this field, especially controlled trials. However, the design choices and interpretation of current study have some important limitations that in our opinion merit more attention.
First, l‘Ami et al set out to assess whether interval prolongation with 50% of adalimumab injections in patients with rheumatoid arthritis doing well is feasible when patients have a trough level …
Contributors AAB and BJFB have both made substantial contributions to the conception, drafting and revising of the work, and both approved the final version and are accountable for all aspects of the work.
Competing interests None declared.
Provenance and peer review Not commissioned; internally peer reviewed.
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