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Reduced salivary secretion contributes more to changes in the oral microbiome of patients with primary Sjögren’s syndrome than underlying disease

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  • Handling editor Josef S Smolen

  • Contributors TAvdM designed the study, performed the analyses and wrote the manuscript. HJMH helped in the design and interpretation of analyses and critically reviewed the manuscript. HB was involved in collecting the clinical information of the patients and reviewed the manuscript. SL helped in designing and performing the laboratory workflow and reviewed the manuscript. AVV helped with statistical design and analysis and reviewed the manuscript critically. AZ, RKW and FKLS were involved in the design, data interpretation and review of the manuscript. FGMK and AV contributed to the conception and design of the study, helped with the interpretation of results and critically reviewed the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval The medical ethical committee of the University Medical Center Groningen.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement 16S rRNA sequencing data is available upon request from the corresponding author.