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In psoriatic arthritis (PsA), ultrasonography (US) plays a growing role in the differential diagnosis and in monitoring treatment response.1 PsA is a heterogeneous disease with different domains and peculiar sites involved.2 Therefore, a dedicated US composite score is needed to monitor disease activity and to identify structural damage progression. A recently published Systematic Literature Review (SLR) identified only two US scores specifically developed for PsA (ie, 5TPD and PsA-Son) and, although these had a good sensitivity to detect inflammation and a good feasibility, they have not been validated in other series.1 3 4 Recently, the Study Group for US of the Italian Society of Rheumatology promoted the Ultrasound in PSoriatic Arthritis TREAtMent (UPSTREAM) study (registered at ClinicalTrial.gov, NCT03330769). UPSTREAM is a multicentre observational prospective cohort study and it represents the first example of integration between clinical examination and US with the aim to identify predictors of achieving minimal disease activity in patients with PsA starting a new course of therapy.
Our first step, towards the development of a US composite score to be used as an outcome in UPSTREAM, was a qualitative research aimed to define those anatomic sites that are considered relevant by rheumatologists, expert in management of PsA and US. For this purpose, a web-based ranking exercise on the relative relevance of different anatomic structures was done.
Bilaterally, seven entheses, eight joints, 10 tendons with sheath, two tendons without sheath and seven anatomic sites for bursae and soft tissues were identified on the basis of the previous SLR and submitted to vote in the survey.1 See table 1 for detailed localisation of each anatomic sites. Within every anatomic structure, a further ranking of sites (eg, for joints: metacarpophalangeal, proximal, distal interphalangeal and metatarsophalangeal joints, wrist, knee) was asked. The between and within weights were calculated as mean of reciprocal rank normalised to 0%–100%. In order to balance for the number of items in each category, the final weight was calculated as product of between and within weights multiplied for the number of items and normalised to 0%–100%. Final ranking identified those items candidate to be incorporated in the scanning US protocol of the UPSTREAM study. To satisfy content validity requirement, at least one item per anatomic structure was included. Twenty rheumatologists, with experience in musculoskeletal US and in the management of PsA, participated in the web exercise. The anatomic structures with a better ranking were: entheses, joints, tendons with sheath, tendons without sheath and ultimately soft tissues and bursae. Considering the overall weight for each site, enthesis of Achilles tendon achieved the best results. The full results are reported in table 1. Through this web-based exercise, we identified the anatomic sites considered useful in revealing typical US changes of PsA and they will be incorporated in the US protocol of the UPSTREAM study. This is a first essential step to assess the content of a simplified US score that will encompass both joint and extra-articular structures, most informative in the US evaluation of PsA.
Handling editor Josef S Smolen
Funding This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent Not required.
Provenance and peer review Not commissioned; externally peer reviewed.
Collaborators Antonella Adinolfi, Irene Azzolin, Francesca Bandinelli, Alberto Batticciotto, Nicola Boffini, Alessandra Bortoluzzi, Greta Carrara, Francesco Paolo Cavatorta, Giovanni Cagnotto, Marta Caprioli, Michele Colaci, Orazio De Lucia, Andrea Delle Sedie, Valentina Denaro, Andrea Di Matteo, Valentina Di Sabatino, Oscar Massimiliano Epis, Ariela Hoxha, Ilaria Farina, Giuseppe Germanò, Georgios Filippou, Emilio Filippucci, Maria Cristina Focherini, Alessandra Gabba, Luca Idolazzi, Giuliana Maria Concetta La Paglia, Filippo Luccioli, Pierluigi Macchioni, Mirco Magnani, Marco Massarotti, Claudio Mastaglio, Luca Navarini, Simone Parisi, Andrea Picchianti Diamanti, Valentina Picerno, Marco Piras, Francesco Porta, Niccolò Possemato, Immacolata Prevete, Bernd Raffeiner, Roberta Ramonda, Viviana Ravagnani, Daniela Rossi, Silvia Rossi, Palma Scolieri, Gianluca Santoboni, Crescenzio Scioscia, Riccardo Terenzi, Ilaria Tinazzi, Carmela Toscano, Carlo Venditti, Alessandro Volpe, Gentiana Vukatana, Giovanni Zanframundo.