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Apoptosis-derived membrane vesicles drive the cGAS–STING pathway and enhance type I IFN production in systemic lupus erythematosus

Authors

  • Yasuhiro Kato Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Osaka, Japan Department of Immunopathology, WPI Immunology Frontier Research Center (iFReC), Osaka University, Osaka, Japan Japan Agency for Medical Research and Development – Core Research for Evolutional Science and Technology (AMED–CREST), Osaka University, Osaka, Japan PubMed articlesGoogle scholar articles
  • JeongHoon Park Department of Immunopathology, WPI Immunology Frontier Research Center (iFReC), Osaka University, Osaka, Japan Graduate School of Medicine, Osaka University, Osaka, Japan PubMed articlesGoogle scholar articles
  • Hyota Takamatsu Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Osaka, Japan Department of Immunopathology, WPI Immunology Frontier Research Center (iFReC), Osaka University, Osaka, Japan Japan Agency for Medical Research and Development – Core Research for Evolutional Science and Technology (AMED–CREST), Osaka University, Osaka, Japan Japan Science and Technology–Core Research for Evolutional Science and Technology (JST–CREST), Osaka University, Osaka, Japan PubMed articlesGoogle scholar articles
  • Hachirou Konaka Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Osaka, Japan Department of Immunopathology, WPI Immunology Frontier Research Center (iFReC), Osaka University, Osaka, Japan Japan Agency for Medical Research and Development – Core Research for Evolutional Science and Technology (AMED–CREST), Osaka University, Osaka, Japan PubMed articlesGoogle scholar articles
  • Wataru Aoki Japan Science and Technology–Core Research for Evolutional Science and Technology (JST–CREST), Osaka University, Osaka, Japan Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto, Japan PubMed articlesGoogle scholar articles
  • Syunsuke Aburaya Japan Science and Technology–Core Research for Evolutional Science and Technology (JST–CREST), Osaka University, Osaka, Japan Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto, Japan PubMed articlesGoogle scholar articles
  • Mitsuyoshi Ueda Japan Science and Technology–Core Research for Evolutional Science and Technology (JST–CREST), Osaka University, Osaka, Japan Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto, Japan PubMed articlesGoogle scholar articles
  • Masayuki Nishide Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Osaka, Japan Department of Immunopathology, WPI Immunology Frontier Research Center (iFReC), Osaka University, Osaka, Japan Japan Agency for Medical Research and Development – Core Research for Evolutional Science and Technology (AMED–CREST), Osaka University, Osaka, Japan PubMed articlesGoogle scholar articles
  • Shohei Koyama Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Osaka, Japan Department of Immunopathology, WPI Immunology Frontier Research Center (iFReC), Osaka University, Osaka, Japan Japan Agency for Medical Research and Development – Core Research for Evolutional Science and Technology (AMED–CREST), Osaka University, Osaka, Japan Japan Science and Technology–Core Research for Evolutional Science and Technology (JST–CREST), Osaka University, Osaka, Japan PubMed articlesGoogle scholar articles
  • Yoshitomo Hayama Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Osaka, Japan Department of Immunopathology, WPI Immunology Frontier Research Center (iFReC), Osaka University, Osaka, Japan Japan Agency for Medical Research and Development – Core Research for Evolutional Science and Technology (AMED–CREST), Osaka University, Osaka, Japan PubMed articlesGoogle scholar articles
  • Yuhei Kinehara Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Osaka, Japan Department of Immunopathology, WPI Immunology Frontier Research Center (iFReC), Osaka University, Osaka, Japan Japan Agency for Medical Research and Development – Core Research for Evolutional Science and Technology (AMED–CREST), Osaka University, Osaka, Japan PubMed articlesGoogle scholar articles
  • Toru Hirano Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Osaka, Japan Department of Immunopathology, WPI Immunology Frontier Research Center (iFReC), Osaka University, Osaka, Japan PubMed articlesGoogle scholar articles
  • Yoshihito Shima Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Osaka, Japan Department of Immunopathology, WPI Immunology Frontier Research Center (iFReC), Osaka University, Osaka, Japan PubMed articlesGoogle scholar articles
  • Masashi Narazaki Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Osaka, Japan Department of Immunopathology, WPI Immunology Frontier Research Center (iFReC), Osaka University, Osaka, Japan PubMed articlesGoogle scholar articles
  • Atsushi Kumanogoh Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Osaka, Japan Department of Immunopathology, WPI Immunology Frontier Research Center (iFReC), Osaka University, Osaka, Japan Japan Agency for Medical Research and Development – Core Research for Evolutional Science and Technology (AMED–CREST), Osaka University, Osaka, Japan Japan Science and Technology–Core Research for Evolutional Science and Technology (JST–CREST), Osaka University, Osaka, Japan PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Hyota Takamatsu, Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan; thyota{at}imed3.med.osaka-u.ac.jp
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Citation

Kato Y, Park J, Takamatsu H, et al
Apoptosis-derived membrane vesicles drive the cGAS–STING pathway and enhance type I IFN production in systemic lupus erythematosus

Publication history

  • Received January 10, 2018
  • Revised May 18, 2018
  • Accepted June 1, 2018
  • First published June 26, 2018.
Online issue publication 
September 12, 2018

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