Article Text

Download PDFPDF
Response to: Quantifying the hepatotoxic risk of alcohol consumption in patients with rheumatoid arthritis by Kremer and Weinblatt
  1. Jenny H Humphreys1,
  2. Ruth Costello1,
  3. Suzanne MM Verstappen1,2,
  4. William G Dixon1
  1. 1 Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester, UK
  2. 2 NIHR Biomedical Research Centre, University of Manchester, Manchester, UK
  1. Correspondence to Dr William G Dixon, NIHR Biomedical Research Centre, University of Manchester, Manchester M13 9PT, UK; will.dixon{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

We thank Drs Kremer and Weinblatt for their interest in our study.1 We agree and acknowledge that lack of biopsies and detailed histology is a limitation of our study.2 Unfortunately good quality data on liver biopsies and ultrasound scans were not available in this retrospective observational study and would not have been systematically performed in all patients, necessitating the use of serum liver function tests (LFTs). However this limitation is balanced against our ability to study a rare outcome in a large number of people. The strengths of observational data are that they reflect ‘real-life’ usage versus a carefully monitored research cohort, and this …

View Full Text


  • Contributors JHH drafted the manuscript. RC, SMMV and WGD all amended and approved the final manuscript.

  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.

Linked Articles