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An Assessment in SpondyloArthritis International Society (ASAS)-endorsed definition of clinically important worsening in axial spondyloarthritis based on ASDAS
  1. Anna Molto1,2,
  2. Laure Gossec3,4,5,
  3. Bhowmik Meghnathi1,6,
  4. Robert B M Landewé7,8,
  5. Désirée van der Heijde9,
  6. Pamir Atagunduz10,
  7. Bassel Kamal Elzorkany11,
  8. Nurullah Akkoc12,
  9. Uta Kiltz13,
  10. Jieruo Gu14,
  11. James Cheng Chung Wei15,16,17,
  12. Maxime Dougados1,2,6
  13. on behalf of the ASAS-FLARE study group
    1. 1 APHP, Rheumatology B Department, Cochin Hospital, Paris, France
    2. 2 Inserm Unit INSERM (U1153): Clinical Epidemiology and Biostatistics, PRES Sorbonne Paris-Cité, Paris, France
    3. 3 UPMC, Sorbonne Universités, Paris, France
    4. 4 Department of Rheumatology, AP-HP, Pitié Salpêtrière Hospital, Paris, France
    5. 5 GRC-UPMC 08 (EEMOIS), Institut Pierre Louis d’Epidémiologie et de Santé Publique, Paris, France
    6. 6 Medicine Faculty, Paris Descartes University, Paris, France
    7. 7 Department of Clinical Immunology & Rheumatology, Amsterdam Rheumatology Center, Amsterdam, The Netherlands
    8. 8 Zuyderland Medical Center, Heerlen, The Netherlands
    9. 9 Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands
    10. 10 Department of Rheumatology, Faculty of Medicine, Marmara University, Istanbul, Turkey
    11. 11 Rheumatology Department, Cairo University, Cairo, Egypt
    12. 12 Internal Medicine/Division of Rheumatology, Dokuz Eylul university school of medicine, Izmir, Turkey
    13. 13 Rheumazentrum Ruhrgebiet, Herne, Germany
    14. 14 Department of Rheumatology and Immunology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
    15. 15 Division of Allergy, Immunology and Rheumatology, Chung Shan Medical University Hospital, Taichung, China
    16. 16 Institute of Medicine, Chung Shan Medical University, Taichung, China
    17. 17 Graduate Institute of Integrated Medicine, China Medical University, Taichung, China
    1. Correspondence to Dr Anna Molto, 27 rue du Faubourg Saint Jacques, 75014, Paris, France; anna.molto{at}


    Introduction In a previous phase, 12 draft definitions for clinically important worsening in axial spondyloarthritis (axSpA) were selected, of which 3 were based on absolute changes in Ankylosing Spondylitis Disease Activity Score (ASDAS)-CRP (ASDAS). The objective here was to select the best cut-off for ASDAS for clinically important worsening in axSpA for use in clinical trials and observational studies.

    Methods An international longitudinal prospective study evaluating stable patients with axSpA was conducted. Data necessary to calculate ASDAS were collected at two consecutive visits (spaced 7 days to 6 months). Sensitivity and specificity of the three cut-offs for change in ASDAS were tested against the patient’s subjective assessment of worsening as the external standard (ie, the patient reporting that he had worsened and felt a need for treatment intensification). Final selection was made by a consensus and voting procedure among Assessment of SpondyloArthritis International Society (ASAS) members.

    Results In total, 1169 patients with axSpA were analysed: 64.8% were male and had a mean age of 41.7 (SD 12.4) years. At the second visit, 127 (10.9%) patients judged their situation as worsened.

    Sensitivity and specificity for an increase of at least 0.6, 0.9 and 1.1 ASDAS points to detect patient-reported worsening were 0.55 (Se) and 0.91 (Sp), 0.38 (Se) and 0.96 (Sp), and 0.33 (Se) and 0.98 (Sp), respectively. The ASAS consensus was to define clinically important worsening as an increase in ASDAS of at least 0.9 points.

    Conclusion This data-driven ASAS consensus process resulted in an ASDAS-based cut-off value defining clinically important worsening in axSpA for use in trials.

    • Spondyloarthritis
    • Outcomes Research
    • Disease Activity
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    The course of axial spondyloarthritis (axSpA) is characterised by periods of flares (clinical worsening) and remission. Current definitions for clinical disease worsening in axSpA are very heterogeneous across clinical trials. This is a particular problem in discontinuation trials, which aim to discontinue the treatment in patients in remission and only resume the treatment in case of disease worsening. The absence of a consensual definition for clinically important worsening of disease activity in axSpA jeopardises the interpretation of—and comparison across—trials.

    The Assessment of SpondyloArthritis International Society (ASAS) is a worldwide independent consortium of experts in spondyloarthritis (SpA), which has developed and validated most of the criteria and outcome measures currently used in SpA clinical trials. This includes the Ankylosing Spondylitis Disease Activity Score (ASDAS) as a disease activity measure with validated cut-offs for various disease activity states and improvements.1 2 ASAS has decided to also define a cut-off for clinically important worsening in axSpA. The first two steps of this process have already been reported:3 first, a systematic literature review of definitions of ‘disease worsening’ in published randomised controlled trials in axSpA was performed, yielding 38 studies using some definition of ‘disease worsening’ and 27 different definitions, most frequently based on Bath Ankylosing Spondylitis Disease Activity Index (BASDAI)4 or pain. Second, a vignette exercise was performed involving 121 ASAS experts and 140 scenarios of disease worsening: each scenario included a change in one of the outcomes (pain, BASDAI, BASDAI plus C reactive protein (CRP) or ASDAS)1. Each ASAS expert judged for each of 46 randomly developed scenarios if the scenario was compatible with disease worsening (yes/no). Receiver-operating characteristic analyses were applied to derive optimal cut-off values for pain (n=3), BASDAI (n=5) and ASDAS (n=4), leading to 12 preliminary definitions of ‘worsening’ in axSpA, based on widely used indices. These results were presented at the 2015 annual ASAS workshop. It was felt that, based on the currently available data, it was impossible to prioritise one of the 12 scenarios, and that arguments for a further reduction of the number of scenarios should come from data observed in clinical practice.

    Thus, we conducted a clinical observational study aiming to evaluate the psychometric properties of the 12 draft definitions of clinically important worsening in axial SpA. The results of the study were presented at the 2017 annual ASAS workshop and a consensus and voting procedure has resulted in a final choice.


    Study design

    An international (including 20 countries), longitudinal (two visits: with an interval between 1 week and 6 months), observational study was conducted in 2016. The study was conducted in agreement with good clinical practice and written informed consent was obtained from all patients. 


    Patients with axSpA with stable disease (no need for treatment change) according to the rheumatologist. 

    Data collected

    Demographics and disease characteristics were collected at baseline, and data on disease activity (including CRP) were collected at both visits. Clinical worsening was defined at the follow-up visit by the patient answering the following question ’Think about all the ways your spondyloarthritis has affected you during the last 48 hours. Compared to the last visit how did you feel during the last 48 hours? Improved/No change/Worse’. When patients answered ‘worse’ they were asked if they considered treatment intensification was necessary (yes/no). Patient’s perception of worsening was defined as the patient reporting that he/she had worsened and that he/she felt there was a need for treatment intensification.


    Pain: question 2 of the BASDAI (back pain) was used. Three pain-based cut-offs were proposed based on the previous exercise3 (see table 2).

    BASDAI: BASDAI was calculated as follows: (fatigue + back pain + peripheral pain + entheseal pain + ((level of morning stiffness + duration of morning stiffness)/2))/5.4

    Five BASDAI cut-offs were proposed3 (table 2).

    ASDAS: the ASDAS formula with CRP was used (ie, ASDAS=0.12 ×  back pain + 0.06 ×  duration of morning stiffness + 0.11 ×  patient global + 0.07 ×  peripheral pain/swelling + 0.58×Ln(CRP + 1)). When the CRP level was below the limit of detection or <2 mg/L, the constant value of 2 mg/L was used to calculate the ASDAS score as recommended.2

    Four ASDAS-based cut-offs were proposed based on the previous exercise, with only three absolute changes:3 an increase in ASDAS of at least 0.6; an increase in ASDAS of at least 0.6 points and a final ASDAS≥1.3; an increase in ASDAS of at least 0.9 points; and an increase in ASDAS of at least 1.1 points.

    Sensitivity (that is: the likelihood to be considered as ‘worse’ by the scenario among all patients considering themselves worse) and specificity (that is: the likelihood to be considered as ‘not worse’ by the scenario, among all patients not considering themselves worse) were tested.

    The results of this analysis were presented at the 2017 annual ASAS workshop together with the previous results from the 2015 consensus (based on the physician’s perspective), followed by a consensus and voting procedure by ASAS members.


    The flow chart of the study is summarised in figure 1: among the 1639 patients included, 1169 patients provided complete data. Patients were predominantly male (64.8%) and had a mean (SD) age of 41.7 (12.4) years. History of radiographic sacroiliitis, MRI sacroiliitis and HLA-B27 positivity were reported in 944 (80.8%), 471 (40.6%) and 807 (69.0%) patients, respectively. Mean and SD at the baseline visit for BASDAI (0–10), ASDAS and CRP were 3.1 (2.3), 2.3 (1.0) 8.4 mg/L (14.5), respectively (table 1).

    Figure 1

    Flow chart of the study.ASDAS, Ankylosing Spondylitis Disease Activity Score; BASDAI, Bath Ankylosing Spondylitis Disease Activity Index; CRP, C reactive protein.

    Table 1

    Patients and disease characteristics (n=1169)

    The mean interval between both visits was 91.2 (SD 51.0) days, and at follow-up visit, means (SD) for BASDAI, ASDAS and CRP were 2.9 (2.2), 2.1 (1.0) and 7.4 (11.8) mg/L, respectively.

    A total of 590 (50.5%), 388 (33.2%) and 191 (16.3%) patients considered their condition as improved, not changed and worsened, respectively. Among the 191 patients reporting a worsening, 127 (66.5%) found that their status required treatment intensification. Thus, 127 (10.8%) patients fulfilled the external standard definition of clinical worsening according to the patient’s perception. Table 2 summarises these performances, along with those from the physician case-vignette exercise in which the external standard was the physician’s perception.3 The three cut-offs of ASDAS change (ie, increase of 0.6, 0.9 and 1.1 points) yielded a sensitivity of 0.55, 0.38 and 0.33, respectively, and a specificity of 0.91, 0.96 and 0.98, respectively.

    Table 2

    Performances of the cut-offs defining clinically important worsening

    In January 2017, the ASAS membership discussed the data at length. Almost all ASAS members were in favour of selecting a cut-off based on the data (67 votes in favour vs 1 against). All members were against defining a cut-off based on pain. No consensus was reached for a BASDAI-based definition due to limited performance of all cut-offs, and 50% of members voted against deciding a cut-off for BASDAI.

    Regarding ASDAS cut-offs, the majority chose the cut-off of at least 0.9 point increase as the definition for clinically important worsening (6 votes in favour of 0.6; 64 votes in favour of 0.9 and no votes in favour of 1.1, n=0 (6 abstained)). Thus, an increase of at least 0.9 points was retained as the ASAS-definition for clinically important worsening in axSpA, to be used in studies.


    This three-step data-driven ASAS consensus process has allowed proposing an ASDAS-based cut-off value defining clinically important worsening in axSpA. The final definition is the result of a comprehensive process involving a systematic literature review, a case-vignette exercise using the physician’s perspective as external standard,3 a real life study on worsening with the patient’s perspective as external standard and a consensus and voting procedure among SpA experts.

    Several cut-offs have already been defined for ASDAS, but only for either improvement changes or status.5 It is worth noting that the minimum clinically important improvement of ASDAS is defined as a decrease of at least 1.1 points, which is a greater change than the change required for the predicate of clinically important worsening. This seemingly paradoxical finding is not unusual: in other disciplines minimal clinically important deterioration (MCID-thresholds for deterioration have often been reported to be lower than for improvement.6 7

    A potential limitation of this study was the discrepancy between patient’s and physician’s perception in terms of sensitivity: indeed, when tested against patient’s perception, cut-offs yielded much lower sensitivity values as compared with physician’s perception. This is not surprising, as patients might report feeling worse already at much lower changes as compared with physicians, and such discrepancies have been grounded in the literature.8

    Second, the 0.9 ASDAS point increase definition had only moderate sensitivity (0.38) against the patient’s perception, but excellent specificity against both patient’s and physician’s perception. This high level of specificity was considered more important than sensitivity since the definition will be used in the context of clinical trials. The definition for clinically important worsening will typically be used in a treatment-withdrawal trial: a patient with SpA will stop treatment if clinical remission has been achieved and will resume the treatment in case of ‘true worsening’. A high specificity reduces the number of ‘false-positive worsenings’ and the subsequent (unnecessary) retreatment.

    In summary, a definition for clinically important worsening in axSpA based on ASDAS has been defined, validated and endorsed by ASAS. This definition should now be used in clinical trials and follow-up studies.


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    • Handling editor Tore K Kvien

    • Contributors AM, LG, MD, RBML, DvdH, conception, design, analysis and interpretation of data. AM: drafting the article. All authors critically revised the manuscript for important intellectual content. All authors read and approved the final manuscript.

    • Funding This study was funded by an ASAS grant.

    • Competing interests None declared.

    • Patient consent Obtained.

    • Ethics approval Ethical approval was locally obtained in all participating centres.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Data sharing statement The data sets generated and/or analysed during the current study are not publicly available due to consent restrictions. Programming codes used for statistical analysis during the current study are available from the corresponding author upon reasonable request.

    • Collaborators A Molto, L Gossec, B Meghnathi, R B M Landewé, D van der Heijde, P Atagunduz, B K Elzorkany, N Akkoc, U Kiltz, J Gu, J C C Wei, M Dougados, S Pandya, V Navarro, I Gaydukova, P Geher, A Spoorenberg, S Aydin, F Pimentel, M Kishimoto, F van Gallen, E Collantes-Estevez, R Schiotis, H Marzo-Ortega, B O’Shea, C Ramos-Remus, M Magrey.

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