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SAT0406 Prevalence of vertebral fractures in axial spondyloarthritis. a systematic review of observational studies
  1. JC Nieto-González1,
  2. R Cubero2,
  3. S Castañeda3,
  4. J Ramírez4,
  5. L Carmona2
  1. 1Rheumatology, Hospital G.U. Gregorio Marañόn
  2. 2Statistics, Instituto de Salud Musculoesquelética
  3. 3Rheumatology, Hospital la Princesa, Madrid
  4. 4Rheumatology, Hospital Clinic, Barcelona, Spain


Background Some studies have described a higher rate of osteoporosis in axial spondyloarthritis (AxSpA). However, there are still some doubts about whether vertebral fractures (VF) should be a concern in AxSpA patients

Objectives To evaluate the prevalence and incidence of VF in AxSpA

Methods A systematic review was performed in Medline, Embase and Cochrane Library databases limited to studies published from Jan/2006 to Dec/2015) in Spanish, Italian and English. Search strategy combined synomyms of AxSpA, fractures, plus a filter study type. We selected cross-sectional or longitudinal studies estimating the prevalence and/or incidence of VF in adult AxSpA patients

Results The search retrieved 3944 references which after screening by title and abstract ended in 90 studies to study in depth. Finally, 12 estudies were included. The majority of the studies evaluated the VF prevalence, and only 2 studies evaluated the incidence of VF. Prevalence estimates depended on VF definitions, varying between 4.1% (clinically diagnosed VF) and 32.4% (morphometric fracture by Genant definition). Table 1 shows all studies included and their data

Table 1

Conclusions The published studies that focus on VF in AxSpA are very heterogeneous, but in general showed a slight increase in the VF prevalence. More studies are need focused on VF incidence in AxSpA

Acknowledgements Funding: This Project was funded by Merck Sharp & Dohme Spain. Merck Sharp & Dohme did not influenced neither the development of the review nor the confection of the abstract.

Disclosure of Interest None declared

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