Background The clinical phase of Rheumatoid arthritis (RA) is preceded by a phase with subclinical inflammation. MRI can detect subclinical inflammation and, at patient level, this is predictive for the development of clinical arthritis. However, at joint level it is unknown how arthritis develops. It is unknown how frequently joints with subclinical inflammation progress to clinical arthritis, and vice versa, how often joints that developed clinical arthritis had local subclinical inflammation during the preceding phase of arthralgia. A longitudinal MRI study in patients that developed arthritis can unravel if arthritis development is restricted to some locations in which the severity of inflammation increases over time or, alternatively, if the process is more generalized with a weak association between the locations of subclinical inflammation and subsequent clinical arthritis.
Objectives This longitudinal study at joint level during progression from pre-RA to RA determined the relation between the location of subclinical inflammation and clinical arthritis over time.
Methods 290 small joints (4 MCPs, 1 wrist, 5 MTPs per person) of 29 patients that presented with arthralgia and developed clinical arthritis were studied with 1.5T MRI at both time-points. MRIs were evaluated for BME, synovitis and tenosynovitis by three readers (ICCs 0.98, 0.96 and 0.97) that were blind to clinical data and the order in time. Subclinical inflammations was defined as presence of BME, synovitis and/or tenosynovitis.
Results The median time between presentation with arthralgia and clinical arthritis development was 17 weeks. At presentation with arthralgia 68 joints had subclinical inflammation and no significant association was found between joint tenderness and the presence of local MRI-detected subclinical inflammation (OR 0.98; 95% CI 0.48–1.9). Over time, 21% of 68 joints had resolution of subclinical inflammation, 60% had persistent subclinical inflammation and 19% developed clinical arthritis. At arthritis development 37 joints were swollen. Of these, 24 (65%) had no prior subclinical inflammation at the time of presentation with arthralgia (Figure).
Conclusions This first longitudinal MRI-study on joint level in pre-RA suggested that the majority of joints that developed clinical arthritis had no (long-lasting) preceding phase with subclinical inflammation.
Disclosure of Interest None declared
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.