Objectives To investigate the value of Parotid Ultrasonography and parotid gland radionuclide imaging in predicting salivary gland biopsy of primary Sjögren's syndrome (pSS).

Methods Sixty - five patients with primary Sjogren 's syndrome and 38 patients with non - Sjogren' s syndrome were enrolled in the Department of Rheumatology and Immunology, Xinjiang Uygur Autonomous Region People 's Hospital from October, 2015 to June, 2016. All patients were accpted the check of Parotid Ultrasonography, Parotid Gland ECT and labial gland biopsy. The data were analyzed statistically.

Results The sensitivity and specificity of Parotid Ultrasonography in pSS were 65% and 76%, respectively. The area under the ROC curve was 0.936±0.024 for the diagnosis of pSS. The positive predictive rate of parotid gland ultrasonography was 84.0% and the negative predictive rate was 94.4%. Parotid scintigraphy in pSS in the sensitivity of 80.0%, specificity of 69.1%. The positive predictive rate of parotid gland radionuclide imaging for labial gland biopsy was 78.9% and the negative predictive rate was 87.5%. The diagnostic value of Parotid Ultrasonography in pSS group is superior to that of parotid gland radionuclide imaging, which can effectively reduce the complication of invasive operation.

Conclusions The diagnosis of pSS by parotid gland ultrasonography is superior to that of parotid gland radionuclide examination. For patients with atypical clinical manifestations who are negative for anti-SSA and/or anti-SSB antibodies, there is no need for a labial biopsy of the labial glands to reduce the number of complications associated with unwanted invasive procedures.

Disclosure of Interest None declared