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FRI0536 The method of calculating the probable value of t-score in patients with multifocal atherocalcification
  1. AN Kokov,
  2. V Masenko,
  3. S Semenov,
  4. O Barbarash
  1. Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation


Objectives To determine probable value of T-score for early detection of osteopenic syndrome in patients with multifocal atherosclerosis based on the multislice computed tomography (MSCT) evaluation of vascular calcification.

Methods 186 male (60±6,7 years) with multifocal atherosclerosis. All the patients underwent the measurement of BMD with X-ray absorptiometry. Moreover, calcium scores (CS) of coronary and brachiocephalic arteries were obtained using Agatston method.

Results T-score values of lumbar vertebrae -1.07 [-1.54;-0.40], T-score of the proximal femur -2.01 [-2.71;-1.49]. Calcification of the coronary arteries: CS=471.8 [118.2;916,8] and carotid arteries: CS=113.9 [44.5;300.8]. Factors that affect the probable value of T-score in patients with known rates of calcification of the coronary and carotid arteries were obtained by regression analysis. These factors were equivalent density of coronary calcinoses (p=0,0046), the volume of the carotid calcifications (p=0,0039), the mass of calcifications of the carotid arteries (p=0,0054) and the presence of a stenosis of the carotid arteries (p=0.0001).The predictive model for estimating the probable value of T-score has been is designed using regression coefficients of each of the factors. The value is equal to the Fisher statistic F=9,52, p-value <0.000001, multiple correlation model's coefficient is 0.753.

Conclusions The results of this study indicate that rates of calcification of the carotid and coronary arteries, resulting in the planned survey on MSCT patients with multifocal atherosclerosis have a high predictive capacity for assessing the probable value of the T-score and early detection of osteopenic syndrome in these patients.

Disclosure of Interest None declared

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