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FRI0139 Prevalence of hyperparathyroidism is higher among rheumatoid arthritis patients compared to the general population: an observational, cohort study
  1. A Emamifar1,
  2. L Stilgren2,
  3. R Hviid Larsen3,
  4. R Asmussen Andreasen1,
  5. IM Jensen Hansen1 4
  1. 1Rheumatology
  2. 2Endocrinology
  3. 3Medicine, Svendborg Hospital, Odense University Hospital, Svendborg
  4. 4DANBIO, Copenhagen, Denmark


Background Patients with Rheumatoid Arthritis (RA) are at increased risk of different comorbidities which may affect long-term prognosis.[1] Primary hyperparathyroidism (PHP) is a metabolic disorder of one or more of the parathyroid glands with a prevalence of 1–7 per 1000 adults.[2]

Objectives To define the prevalence of PHP in patients with RA.

Methods All RA patients who were registered in the local part of Danish Danbio registry were included in this study. Patients'demographic data and serology results (rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibody (anti-ccp)) were extracted from Danbio. Patients' electronic hospital records including laboratory results (Parathyroid hormone (PTH) and calcium levels) were reviewed to reveal if they had been diagnosed with PHP as well.

Results 1035 RA patients were included in this study [table 1]. Prevalence of PHP was 2.8% (29/1035). RA Patients with PHP had significant longer disease duration compared to patients with isolated RA (p=0.003). There was no significant difference between RA patients with and without PHP with respect to age, gender, RF and anti-ccp positivity (Table 1).

Table 1.

Association of PHP with age, gender, disease duration, Rheumatoid Factor and Anti-ccp in RA patients

Conclusions Clinicians should pay special attention to higher prevalence of PHP among RA patients compared to the general population. Presence of PHP in RA patients may aggravate the effect of RA on bones and joints by means of interaction with cytokines and inflammatory markers involved in RA. Concurrent PHP can be diagnosed at early stage by testing PTH and calcium levels which minimize the future morbidities e.g. fracture due to osteoporosis.


  1. Dougados M, Soubrier M, Antunez A, et al. Prevalence of comorbidities in rheumatoid arthritis and evaluation of their monitoring: results of an international, cross-sectional study (COMORA). Ann Rheum Dis 2014;73:62–8.

  2. Yeh MW, Ituarte PH, Zhou HC, et al. Incidence and prevalence of primary hyperparathyroidism in a racially mixed population. J Clin Endocrinol Metab 2013;98:1122–9.


Acknowledgements We thank Mrs. Maryam Mousavi for her contribution to data collection.

Disclosure of Interest None declared

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