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Poster Presentations
Validation of outcome measures and biomarkers
THU0681 Baseline ESSDAI/DAS scores in 8061 patients with primary sjÖgren syndrome: characterization of systemic disease
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  1. P Brito-Zerόn1,2,
  2. N Acar-Denizli3,
  3. M Zeher4,
  4. A Rasmussen5,
  5. X Li6,
  6. C Baldini7,
  7. J-E Gottenberg8,
  8. D Danda9,
  9. L Quartuccio10,
  10. G Hernandez-Molina11,
  11. AA Kruize12,
  12. S-H Park13,
  13. M Kvarnström14,
  14. S Praprotnik15,
  15. D Sene16,
  16. A Alunno17,
  17. R Solans18,
  18. T Mandl19,
  19. Y Suzuki20,
  20. M Rischmueller21,
  21. G Nordmark22,
  22. G Fraile23,
  23. P Wiland24,
  24. H Bootsma25,
  25. T Nakamura26,
  26. V Valim27,
  27. R Giacomelli28,
  28. R Seror29,
  29. V Devauchelle-Pensec30,
  30. B Hofauer31,
  31. M Bombardieri32,
  32. V Trevisani33,
  33. D Hammenfors34,
  34. A Minniti35,
  35. SG Pasoto36,
  36. J Morel37,
  37. S Retamozo38,
  38. TA Gheita39,
  39. F Atzeni40,
  40. C Vollenveider41,
  41. X Mariette29,
  42. M Ramos-Casals2,
  43. on behalf of EULAR-SS TF Big Data Consortium
  1. 1Hosp CIMA-Sanitas
  2. 2Hosp Clínic, Barcelona, Spain
  3. 3Msgsü, Istanbul, Turkey
  4. 4Univ, Debrecen, Hungary
  5. 5OMRF, Oklahoma, United States
  6. 6Anhui Hosp, Hefei, China
  7. 7Univ, Pisa, Italy
  8. 8Univ, Strasbourg, France
  9. 9CMC, Vellore, India
  10. 10Santa Maria, Udine, Italy
  11. 11INCMNSZ, México, Mexico
  12. 12UMC, Utrecht, Netherlands
  13. 13Catholic Univ, Seoul, Korea, Republic Of
  14. 14Karolinska Instit, Stockholm, Sweden
  15. 15UMCL, Ljubljana, Slovenia
  16. 16Lariboisière Hosp, Paris, France
  17. 17Univ, Perugia, Italy
  18. 18Hosp Vall Hebron, Barcelona, Spain
  19. 19Lund Univ, Malmö, Sweden
  20. 20Univ, Kanazawa, Japan
  21. 21TQEH, Adelaide, Australia
  22. 22Univ, Uppsala, Sweden
  23. 23Hosp Ramόn Cajal, Madrid, Spain
  24. 24Med Hosp, Wroclaw, Poland
  25. 25Univ, Groningen, Netherlands
  26. 26Univ, Nagasaki, Japan
  27. 27UFES, Vitόria, Brazil
  28. 28Univ, L'Aquila, Italy
  29. 29Univ Sud, Paris
  30. 30Univ, Brest, France
  31. 31TUM, München, Germany
  32. 32QMUL, London, United Kingdom
  33. 33UNIFESP, Sao Paulo, Brazil
  34. 34Haukeland Hosp, Bergen, Norway
  35. 35Sapienza Univ, Rome, Italy
  36. 36USP, Sao Paulo, Brazil
  37. 37Univ, Montpellier, France
  38. 38INICSA, Cordoba, Argentina
  39. 39Univ, Cairo, Egypt
  40. 40L.Sacco Univ, Milan, Italy
  41. 41German Hosp, Buenos Aires, Argentina

Abstract

Objectives To characterize and quantify systemic involvement at diagnosis in a large international cohort of patients with primary Sjögren's syndrome (SS).

Methods The Big Data Sjögren Project was formed in 2014 to take a “high-definition” picture of primary SS at diagnosis by merging international databases (9302 consecutive patients from 21 countries of the 5 continents). The main features (including ESSDAI/DAS) at diagnosis were analysed.

Results Baseline ESSDAI was available in 8061 patients (93% female, mean age 53yrs). The mean ESSDAI score at diagnosis of the entire cohort was 6.4±7.9. In 1498 patients (19%), score at diagnosis was 0, while 681 (8%) presented with high activity in at least one domain. The main systemic features at diagnosis were biological (51%), articular (38%), haematological (24%) and glandular (22%). Low DAS was reported in 4480 (56%) patients, moderate DAS in 2483 (31%) and high DAS in 1098 (14%) patients. The mean baseline ESSDAI was higher the younger the patient was (p<0.001), higher in White patients (6.9 vs 5.1, p<0.001), males (8.4 vs 6.2, p<0.001), those with positive ocular (6.7 vs 4.9, p<0.001) or oral (6.8 vs 6.2, p=0.016) tests, and those with ANA (6.9 vs 4.5, p<0.001), RF (7.5 vs 5.8, p<0.001) and anti-Ro/La antibodies (7.2 vs 4.4, p<0.001). Logistic regression identified as independent variables White ethnicity (OR 3.07), abnormal ocular tests (OR 2.14), ANA (OR 1.67) and Ro/La autoantibodies (OR 2.78).

Conclusions This is the largest series of patients with primary SS in whom the ESSDAI score has been evaluated. Primary SS is undeniably a systemic disease even at the time of diagnosis, with nearly 80% of patients showing an ESSDAI score >0.

Disclosure of Interest None declared

https://doi.org/10.1136/annrheumdis-2017-eular.4472

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