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THU0425 The first metatarsophalangeal joint (MTP1) is not the main localization of gout at diagnosis in sub-saharan africa
  1. F Kemta Lekpa,
  2. MS Doualla,
  3. H Namme Luma
  1. Service de Médecine Interne, Douala General Hospital, Douala, Cameroon


Background Numerous data in sub-Saharan Africa suggest that MTP1 is not the hallmark of gout (1–5).

Objectives We carried out this study with the aim to determine the joint most involved at the time of diagnosis of gout in Cameroon.

Methods We performed a cross-sectional study in all outpatients seen at the Rheumatology unit of the Douala General Hospital, Cameroon, between 2004 and 2014. We included patients with diagnosis of gout according to ACR criteria 1977.

The main characteristics of gout at diagnosis were collected, particularly the joints involved.

A p<0.05 was significant.

Results At the end of this study, 511 patients (415 men and 96 women) with the diagnosis of gout were included. The mean age was 55.9±10.8 years.

Joint pain (n=508, 99.4%) was the leading reason for consultation at the time of diagnosis. The knees (n=300, 62.6%)), ankles (n=187, 39.0%) and MTP1 (n=128, 26.7%) were the most affected joints. Table 1 presents the frequency of the joints affected, comparing our results with those of the other African series.

There was no difference between MTP1 and others joints location (particularly knees and ankles) according to age, sex, place of residence, duration of disease, uric acid level, and associated comorbidities (p>0.05).

Table 1.

Comparison of the most affected joints of the different African series*

Conclusions MTP1 is not the joint most involved at the time of diagnosis of gout in sub-Saharan Africa. Diagnosis of gout should be considered before any inflammatory knee and ankle pain in patients from sub-Saharan Africa. Genetic studies would provide a better understanding of this feature.


  1. Kodio B, et al. Afr J Rheumatol. 2015 3(1): 22–26.

  2. Adelewo OO, et al. Afr J Rheumatol. 2014 1(2): 23–28.

  3. Singwé-Ngandeu M, et al. Mali Medical. 2009 24:17–20.

  4. Mijiyawa M, et al. Joint Bone Spine. 2000;67(5):441–5.

  5. Cassim B, et al. Ann Rheum Dis. 1994 Nov;53(11):759–62.


Disclosure of Interest None declared

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