Article Text

Download PDFPDF

SP0131 Autoimmune atherosclerosis
  1. Z Szekanecz
  1. Department of Rheumatology, University of Debrecen, Faculty of Medicine, Debrecen, Hungary


Arthritides have been associated with accelerated atherosclerosis to increased vascular disease risk. Traditional risk factors, as well as the role of systemic inflammation including cytokines, chamokines, proteases, autoantibodies, adhesion receptors and others have been implicated in the development of these vascular diseases. Accelerated atherosclerosis and increased cardio- and cerebrovascular morbidity and mortality have been observed in rheumatoid arthritis (RA) and spondyloarthropathies (SpA).

Endothelial dysfunction, overt atherosclerosis and vascular stiffness may be indicated by brachial artery flow-mediated vasodilation (FMD), common carotid intima-media thickness (ccIMT) and aortic pulse-wave velocity (PWV), respectively. These abnormalities have been described in most inflammatory rheumatic diseases. While ccIMT and stiffness are relatively stable, FMD may be influenced by many confounding factors.

In addition to traditional vasculoprotection, immunosuppressive agents including corticosteroids, traditional and biologic DMARDs may have significant vascular and metabolic effects. The official EULAR recommendations on the assessment and management of cardiovascular disease in arthritides have been published.

Disclosure of Interest None declared

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.