Background All-cause and cause-specific mortality is increased in patients with systemic lupus erythematosus (SLE) and Rheumatoid Arthritis (RA) when compared to the general population. Mortality can be attributed to the disease per se, side effects of drugs and effect of comorbidities. The survival of patients has improved over the past years when compared to historical controls

Objectives The objective is to describe all-case of mortality in patients with SLE and RA in a university hospital.

Methods This is an observational, descriptive, and cross-sectional study. We included all patients with SLE and RA hospitalized during 1998 to 2014. The cause of death was obtained from medical records and classified according to International Classification of Diseases (ICD)-10. We made a descriptive analysis of all-cause of mortality of both diseases.

Results We analyzed 1,330 medical records, of which 215 died in hospital. The respiratory insufficiency was the most common mortality diagnosis in both diseases (RA 29%, SLE 24.1%), followed by sepsis (RA 25%, SLE 20.4%). The all-cause of mortality of SLE and RA are shown in Table 1. Of the 467 RA hospital admissions, the 5.1% died, and of the 863 SLE hospital admissions, the 22.1% died.

Conclusions Advances in the diagnosis and treatment of SLE and RA, have decreased the morbidity and mortality of the two diseases. Infectious and cardiovascular pathologies were the most frequent causes of death.

Disclosure of Interest None declared