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AB0991 Prevalence of fibromyalgia and depression in patients with autoimmune /inflammatory syndrome induced by adjuvants compared to patients with systemic sclerosis
  1. O Vera-Lastra,
  2. P Blas Hernadez,
  3. A Sánchez-Rodríguez,
  4. LJ Jara
  1. Internal Medicine, Hospital Especialidades CMN la Raza. Instituto Mexicano Seguro Social, Mexico City, Mexico


Background Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) has been associated with previous exposure to various agents such as mineral oil, silicone and vaccines, which act as adjuvants eliciting chronic stimulation of the immune system and manifestation of autoimmune diseases. There is little information about fibromyalgia (FM), depression and the deterioration of the quality of life in ASIA patients.

Objectives To determine the prevalence of FM, depression and both in ASIA patients associated to mineral oil versus systemic sclerosis (SSc) patients.

Methods A comparative cross-sectional study was performed in patients with ASIA according to Shoenfeld's criteria associated to injection of mineral oil with cosmetic purposes. The prevalence of fibromyalgia according to criteria of ACR, depression by Beck questionnaire and quality of life with FS-36 in patients with ASIA versus patients with systemic sclerosis matched by age were evaluated.

Results There were 100 women, 50 ASIA patients (mean age 49±9.7 years) compared to 50 SSc patients (mean age 49±10 years). Of patients with ASIA, 40 patients had non-specific rheumatic disease and 10 met ACR criteria for SSc in 4 patients, SLE 3 and overlap syndrome 1 (SLE plus SSc) and rheumatoid arthritis 2. In ASIA vs. SSc we found depression in 72% vs 46% respectively, p<0.005, fibromyalgia in 66 vs 48%, p<0.008 and fibromyalgia plus depression in 56% vs. 28, p<0.005. Patients with ASIA had a worse quality of life than SSc by SF36 and the most affected parameter was the emotional one.

Conclusions ASIA patients associated to injection of mineral oild had higher prevalence of depression, fibromyalgia and greater deterioration of quality of life compared to SSc patients. There is a possible link between ASIA, depression and FM.


  1. Agmon-Levin N et al. Chronic fatigue syndrome and fibromyalgia following immunization with hepatitis Bvaccine:another angle of autpimmune (auto-inflammatory)syndrome induced by adjuvants (ASIA). Immunol Res 2014;60:376–82.

  2. Vera Lastra o, et al. Autoimmune /Inflammatory syndrome induced by adjuvants (Shoenfeld's syndrome):clinical and immunological spectrum. Expert Rev Clibn Immunol 2013;9:361–73.

  3. Jara LJ; et al. Severe manifestation of autoimmune syndrome induced by adjuvants (shoenfeld's syndrome. Immunol Res 2016 Jul 13.


Disclosure of Interest None declared

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