Objectives To determine probability of the presence of osteopenic syndrome in patients with multifocal atherosclerosis based on the multislice computed tomography (MSCT) evaluation of vascular calcification.
Methods 186 male (60±6,7 years) with multifocal atherosclerosis. All the patients underwent the measurement of BMD with X-ray absorptiometry. Moreover, calcium scores (CS) of coronary and brachiocephalic arteries were obtained using Agatston method.
Results Among the patients had a high prevalence of osteopenia syndrome (87.1%). According to X-ray absorptiometry T-score values of lumbar vertebrae -1.07 [-1.54; -0.40], T-score of the proximal femur -2.01 [-2.71; -1.49]. We also found a large amount of calcification of the coronary arteries according MSCT: calcium score (CS) 471.8 [118.2; 916,8]. Calcification of the carotid arteries in patients of the study group was less pronounced: CS 113.9 [44.5; 300.8], but noted significant direct relationship between the degree of calcification of different vascular beds (r=0,35, p<0,05). We have data on the significant inverse association between bone density and a coronary artery calcification (r=-0,29, p<0,05), and the carotid artery (r=-0,22, p<0,05) by using Spearman rank correlations. Factors that affect the probability of osteopenic syndrome (according X-ray absorptiometry) in patients with known rates of calcification of the coronary and carotid arteries were obtained by regression analysis. These factors were coronary CS (p=0.012), carotid CS (p=0.034), the mass of calcifications of the carotid arteries (p=0.025) and the presence of a stenosis of the carotid arteries (p=0.026). The predictive model for estimating the probability of the presence of osteopenia in patients with multifocal atherosclerosis has been is designed using regression coefficients of each of the factors. As a result, ROC-analysis of the area under the ROC-curve for this prediction model was 0.792 (p=0.0001). The model was tested in the study sample. The specificity of the model was 72.1%, sensitivity of the model was 80.2%.
Conclusions The study results suggest that indicators of calcification of the carotid and coronary arteries resulting from a routine examination by MSCT of patients with multifocal atherosclerosis have a high predictive capacity for assessing the probability of the presence of osteopenic syndrome in this category of patients.
Disclosure of Interest None declared
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