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AB0811 Hyaluronic acid intra-articular injection versus oral atorvastatin in the treatment of knee osteoarthritis
  1. M Jokar,
  2. Z Mirfeizi,
  3. K Hashemzadeh,
  4. H Zarei
  1. Mashhad University of Medical Sciences, Mashhad, Iran, Islamic Republic Of


Background Osteoarthritis is a degenerative joint disorder of articular cartilage and is the most common type of arthritis in the elderly. Some studies have suggested that Hyaluronic acid1 and atorvastatin2 may have a role in the treatment of osteoarthritis.

Objectives The purpose of the present study was to investigate and compare the potential effects of Hyaluronic acid and Atorvastatin on the symptoms of knee osteoarthritis.

Methods We conducted an open, randomized, parallel study on patients with knee osteoarthritis. Eligible patients were those who met the ACR criteria of primary knee osteoarthritis, radiologically ascertained grade I or II of knee osteoarthritis on the Kellgren-Lawrence scale, had a pain score≥60 (maximum 100) and age 50–70 years. Patients are not eligible if they had secondary osteoarthritis, systemic disease like diabetes, history of inflammatory arthritis, sever knee deformity (varus or valgus >50 degree), history of coagolopathy, sever cardiovascular disease, and active infections. Patients were enrolled from outpatient clinic of Imam Reza Hospital, Mashhad, Iran. We divided them randomly into two groups; Group 1 (n=35) received intra-articular Hyaluronic acid each week for three weeks, and group 2 (n=35) received oral atorvastatin 40 mg/day orally for six months. Symptoms were assessed by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) at baseline and every month up to 6 months.

Results Twenty eight patients (40%) were male and 42 patients (60%) were female. There was not a significant difference between 2 groups regard to sex (P=0.626). Mean age of patients was 57.9±1.1 years. Groups mean age did not differ significantly (P=0.710). The pain and function scores were significantly decreased only in the Hyaluronic acid group in the second month (P<0.001). There was not any significant improvement in any group in the next months (figure 1).

Conclusions Intra articular Hyaluronic acid improved the pain and function of patients with knee osteoarthritis in the second months after injection. Atorvastatin did not have any effect on the knee osteoarthritis symptoms during 6 months.


  1. Petrella RJ, Petrella M. A prospective, randomized, double-blind, placebo controlled study to evaluate the efficacy of intraarticular hyaluronic acid for osteoarthritis of the knee. J Rheumatol 2006; 33:951.

  2. Pathak NN, Lingaraju MC, Balaganur V, Kant V, More AS, Kumar D, Kumar D, Tandan SK. Anti-inflammatory and chondroprotective effects of atorvastatin in a cartilage explant model of osteoarthritis. Inflamm Res. 2015 Apr;64(3–4):161–9.


Disclosure of Interest None declared

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