Background The Psoriatic Arthritis Impact of Disease 12-item questionnaire (PsAID12) has been developed to measure impact of Psoriatic Arthritis (PsA) for purposes of monitoring and clinical management. Although validated in patients with longstanding disease, data on validity and sensitivity to change in early PsA is lacking.
Objectives We aim to relate change in disease activity to change in PsAID12 score in early PsA and evaluate which PsAID domains are more likely to change.
Methods Patients with a new diagnosis of PsA were included in the Dutch southwest Early Psoriatic Arthritis cohoRt (DEPAR). For this analysis, patients that have PsAID12 (range 0–10) and Composite Psoriatic Disease Activity Index (CPDAI, range 0–15) data at two consecutive visits (i.e. 3 months apart) within the first year were included. In case multiple periods per patients were available, the first time period was chosen. The change in PsAID is compared to the change in disease activity over this period, measured with the CPDAI using Spearman's correlation coefficient. Change in score on individual domains of the PsAID was analysed in subgroups of patients that perceived improvement in health and those that perceived worsening. The SF-36 question on self-perceived change in health was used to determine these subgroups.
Results 143 unique patients had at least one period with two PsAID and CPDAI measurements (67 from baseline-3 months, 26 3–6 months, 25 6- 9 months and 25 9–12 months). Mean age was 51 (SD 13.7) and 70 (49%) were male. The initial median PsAID was 3.35 (IQR 1.4–5.1) and the subsequent score was 2.25 (0.95–4.8 with a mean delta of 0.52 (P<0.01). Median first CDPAI score was 4 (2–7) and 3 (1–5) for the second with a mean delta of 0.45 (P<0.05). The difference in PsAID score was significantly but moderately correlated with the difference in CPDAI (Spearman's rho 0.267, P=0.0013). 58 patients (41%) report a better health status compared to 3 months ago. Figure 1 shows that patients with self-perceived improvement of health have the highest improvement in pain and only domains of skin problems and embarrassment/shame did not improve significantly. Patients reporting worsening of health (n=29) only have significantly lower scores in fatigue, discomfort and social domains.
Conclusions Improvement in CPDAI disease activity is significantly but moderately associated with improvement in PsAID score, with the biggest improvement in the pain domain in patients with a self-reported improvement of health.
Disclosure of Interest None declared
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