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AB0568 Application of ozonated water in oral ulcer patients with behcet's disease
  1. H Miao,
  2. L Zhang,
  3. G Zhang,
  4. K Xu
  1. Rheumatology, Shanxi Dayi Hospital, Taiyuan, China


Background Behcet's disease is a systemic vasculitis disease of unknown etiology. Oral ulcer is the most common symptoms, the ulcer is various, the swelling and pain is obvious, and it is easy to recurrent, these symptoms affected the patient's diet and life seriously.Therefore, it is important to care the patients with Behcet's disease of oral ulcer.The ozonated water had many functions such as immune activation and immune regulation, it can induce the production of many cytokines,promote the repairment of oral epithelium.At the same time,the ozonated water had a direct effect on the nerve endings,it played a better analgesic effect, it was widely used in oral mucositis which induced by chemotherapy.But there were few studies about application ozonated water in the patients with Behcet's disease of oral ulcer, it was not widely used in clinical practice.

Objectives Apply the ozonated water in patients with Behcet's disease,observe the effectiveness in patients with Behcet's disease of oral ulcer.

Methods From June 2014 to June 2016,82 cases of hospitalized patients with Behcet's disease were randomly divided into study group and control group (n=41), the control group used nursing method of gentamycin sulfate solution and nystatin solution gargle alternatively,the research group using ozonated water gargle,observe and evaluate the healing effect of two groups of patients.

Results The research group had significant improvement in healing oral ulcer and relieving pain (P<0.05).

Conclusions Ozonated water had a perfect effect in patients with Behcet's disease of oral ulcer.


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Disclosure of Interest None declared

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