Article Text

AB0505 Does vitamin d deficiency contribute to cognitive dysfunction in patients with systemic lupus erythematosus?
  1. HA Hussein1,
  2. NA Fouad2,
  3. L Daker3,
  4. A Elamir4,
  5. SR Mohamad4
  1. 1Internal Medicine, Fayoum University, Cairo
  2. 2Rheumatology
  3. 3Neurology
  4. 4Medical Biochemistry, Fayoum University, Fayoum, Egypt


Background Neurocognitive impairment is one of the most common SLE manifestations. However, its pathophysiology remains poorly understood [1]. Vitamin D deficiency is a potential risk factor for cognitive impairment [2,3].

Objectives Our aim is to evaluate the relationship between 25(OH)D3 level and cognitive performance in patients with SLE.

Methods Thirty Egyptian patients diagnosed as systemic lupus erythematosus and their age and sex matched controls were subjected to a battery of neuropsychological evaluation by California Verbal Learning Test (CVLT-II), Controlled Oral Word Association Test (COWAT) and Trail making test and evaluation of depression by using Beck Depression Inventory (BDI). Serum level of 25(OH)D3 was measured in cases and controls.

Results Patients with SLE had a worse performance than controls in verbal memory total recall, executive function and phonemic verbal fluency as there was a statistically significant difference in CVLT-II total recall, Trail making test and phonemic-COWAT respectively. There was no significant difference between the patients and controls in Beck Depression Inventory (BDI). There was a significant positive correlation between the vitamin D level and executive function assessed by trail making test (r =0.399, p=0.03).

Table 1.

Comparison of psychometric tests between the patients and controls

Table 2.

Correlations between vitamin D level and measures of cognitive among cases

Conclusions Vitamin D deficiency in patients with SLE could have a significant impact on their cognitive performance.


  1. Carbotte R. M., Denburg S. D. and Denburg J. A., “Cognitive Dysfunction and Systemic Lupus Erythematosus,” In: R. G. Lahit, Ed., Systemic Lupus Erythematosus, Churchill Livingstone, New York, 1992, pp. 865–881.

  2. Etgen T, Sander D, Bickel H, Sander K, Forstl H. Vitamin D deficiency, cognitive impairment and dementia: a systematic review and meta-analysis. Dement Geriatr Cogn Disord. 2012; 33:297–305.

  3. Balion C, Griffith LE, Strifler L, Henderson M, Patterson C, Heckman G, et al. Vitamin D, cognition, and dementia: a systematic review and meta-analysis. Neurology. 2012; 79:1397–405.


Disclosure of Interest None declared

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