Article Text

Download PDFPDF

AB0329 Do anxious or depressive rheumatoid arthritis patients on biotechnologic therapy have worse disease activity, function and quality of life?
  1. J Borges1,
  2. N Madeira1,
  3. A Cardoso2,
  4. L Cunha-Miranda1,
  5. F Barcelos1,
  6. C Miguel1,
  7. C Silva1,
  8. S Fernandes1,
  9. R Trinca3,
  10. D Medeiros1,
  11. R Campanilho-Marques1,
  12. H Santos1,
  13. R Leitão1,
  14. A Faustino1
  1. 1Rheumatology
  2. 2Nutrition
  3. 3Nursing, Instituto Portugues de Reumatologia, Lisboa, Portugal


Background Depression, anxiety and fatigue are common symptoms in rheumatoid arthritis (RA) patients, and seem to influence disease activity, pain, quality of life (QoL) and treatment response.

Objectives To assess disease activity, function and QoL in RA patients with symptoms of anxiety/depression.

Methods Observational, cross-sectional study including RA patients on bDMARD followed at our centre, registered at with ≥1 evaluation from 2015/11 to 2016/07. Clinical data including DAS28, CDAI, SDAI, TJC, SJC, patients' and physicians' pain/global assessments (VAS), ESR, CRP, HAQ, EQ5D, HADS score (anxiety and depression domains, cutoff ≥8) and FACIT-F were collected. Data were analyzed using Mann-Whitney, Qui-Squared and Spearman correlation, p<0.05.

Results 182 patients enrolled, 84.6% female, mean: age at 1st bDMARD 53.8±11.1; time since diagnosis 16.2±9.3 years; DAS28 3.54±1.3; CDAI 10.2±9.6; SDAI 11.2±10.4; HAQ 0.97±0.6; HADS-Anxiety 7.13±4.5; HADS-Depression 6.62±4.54, FACIT-F 35.1±9.2, EQ-5D 0.36±0.2. 77 (44.5%) patients scored ≥8 in the HADS-Anxiety domain and 71 (41.0%) scored ≥8 in the HADS-Depression domain. Comparison of depressive vs non-depressive and anxious vs non-anxious groups appears on table 1. There was a correlation of HADS-Anxiety with DAS28 (r=0.391, p<0.001), CDAI (r=0.441, p<0.001), SDAI (r=0.426, p<0.001), HAQ (r=0.509, p<0.001), FACIT-F (r=-0.669, p<0.001) and EQ5D (r=-0.592, p<0.001). There was a correlation of HADS-Depression with DAS28 (r=0.389, p<0.001), CDAI (r=0.455, p<0.001), SDAI (r=0.439, p<0.001), HAQ (0.596, p<0.001), FACIT-F (r=-0.679, p<0.001) and EQ5D (r=-0.659, p<0.001).

Table 1.

Comparison of anxious vs non-anxious and depressive vs non-depressive patients

Conclusions Anxious or depressive patients showed higher disease activity, especially in measures with some subjectivity (such as TJC and PGA) but not regarding ESR or CRP and worse function and QoL. This fact must be taken into account when evaluating therapeutic efficacy.

Disclosure of Interest None declared

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.