Article Text

Download PDFPDF

AB0324 Is low serum vitamin d level associated with increased neuropathic pain in rheumatoid arthritis patients? a cross-sectional study
  1. H Yesil1,
  2. U Sungur2,
  3. S Akdeniz3,
  4. G Gurer3,
  5. B Yalcın4,
  6. U Dundar1
  1. 1Physical Medicine and Rehabilitation, Afyon Kocatepe University, Afyonkarahisar
  2. 2Physical Medicine and Rehabilitation, Ege University, Faculty of Medicine, Izmir
  3. 3Physical Medicine and Rehabilitation, Adnan Menderes University, Faculty of Medicine, Aydın
  4. 4Afyon Kocatepe University, Afyonkarahisar, Turkey


Background Rheumatoid arthritis (RA) is a systemic, autoimmune, progressive condition characterised by progressive synovitis with resultant joint destruction, functional disability and significant pain. Recent experimental data indicates that there may be a neuropathic component of pain perception in RA.

Objectives The aim of this study was to examine the development of neuropathic pain (NP) in patients with RA and its relationship with vitamin D.

Methods We used the Leeds assessment of neuropathic symptoms and signs (LANSS) questionnaire to evaluate NP in 93 patients with RA. Clinical parameters included general demographics, and disease activity scores were evaluated. The patients also completed Short form-36 survey, and Health Assessment Questionnaire.

Results Of all the patients who were eligible for the study, 75 were female (80.6%). Mean serum vitamin D level of the participants was calculated to be 22.8±11.9 ng/mL. According to the LANSS questionnaire 31 patients (33.3%) were classified as having NP. There was a negative correlation between vitamin D levels and LANSS value (p=0.001). We have determined that patients with vitamin D serum levels below 20 ng/mL have significantly higher NP positivity rate (p=0.012), besides they have 5.8 times more risk of developing NP when compared to patients with vitamin D serum levels ≥30 ng/mL.

Conclusions We conclude that Vitamin D deficiency is prevalent in RA patients with NP. Once it is the right diagnosis, Vitamin D deficiency treatment is relatively easy, safe, inexpensive and with satisfactory outcomes; therefore, an underlying vitamin D deficiency should be explored in the etiology of NP in patients with RA.


  1. Bellucci E, Terenzi R, La Paglia GM, Gentileschi S, Tripoli A, Tani C, Alunno A. One year in review 2016: pathogenesis of rheumatoid arthritis. Clin Exp Rheumatol. 2016; 34(5):793–801.

  2. Koop SM, Klooster PM, Vonkeman HE, Steunebrink LM, van de Laar MA. Neuropathic-like pain features and cross-sectional associations in rheumatoid arthritis. Arthritis Research & Therapy.2015; 17:237.

  3. Shehab D, Jarallah KA, Abdella N, Mojiminiyi OA, Mohamedy HA. Prospective Evaluation of the Effect of Short-Term Oral Vitamin D Supplementation on Peripheral Neuropathy in Type 2 Diabetes Mellitus. Med Princ Pract. 2015; 24:250–256.


Disclosure of Interest None declared

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.