Clinical benefit of 1-year certolizumab pegol (CZP) add-on therapy to methotrexate treatment in patients with early rheumatoid arthritis was observed following CZP discontinuation: 2-year results of the C-OPERA study, a phase III randomised trial

Tatsuya Atsumi; Yoshiya Tanaka; Kazuhiko Yamamoto; Tsutomu Takeuchi; Hisashi Yamanaka; Naoki Ishiguro; Katsumi Eguchi; Akira Watanabe; Hideki Origasa; Shinsuke Yasuda; Yuji Yamanishi; Yasuhiko Kita; Tsukasa Matsubara; Masahiro Iwamoto; Toshiharu Shoji; Osamu Togo; Toshiyuki Okada; Désirée van der Heijde; Nobuyuki Miyasaka; Takao Koike

doi:10.1136/annrheumdis-2016-210246

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Clinical and epidemiological research

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Clinical benefit of 1-year certolizumab pegol (CZP) add-on therapy to methotrexate treatment in patients with early rheumatoid arthritis was observed following CZP discontinuation: 2-year results of the C-OPERA study, a phase III randomised trial

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Tatsuya Atsumi Hokkaido University Graduate School of Medicine, Sapporo, Japan PubMed articles Google scholar articles
Yoshiya Tanaka The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan PubMed articles Google scholar articles
Kazuhiko Yamamoto Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan PubMed articles Google scholar articles
Tsutomu Takeuchi Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan PubMed articles Google scholar articles
Hisashi Yamanaka Tokyo Women's Medical University, Tokyo, Japan PubMed articles Google scholar articles
Naoki Ishiguro Nagoya University Graduate School and Faculty of Medicine, Nagoya, Japan PubMed articles Google scholar articles
Katsumi Eguchi Rheumatic and Collagen Disease Center, Sasebo Chuo Hospital, Sasebo, Nagasaki, Japan PubMed articles Google scholar articles
Akira Watanabe Tohoku University, Sendai, Japan PubMed articles Google scholar articles
Hideki Origasa Division of Biostatistics and Clinical Epidemiology, The University of Toyama Graduate School of Medicine, Toyama, Japan PubMed articles Google scholar articles
Shinsuke Yasuda Hokkaido University Graduate School of Medicine, Sapporo, Japan PubMed articles Google scholar articles
Yuji Yamanishi Hiroshima Rheumatology Clinic, Hiroshima, Japan PubMed articles Google scholar articles
Yasuhiko Kita Yokohama Rosai Hospital, Yokohama, Japan PubMed articles Google scholar articles
Tsukasa Matsubara Matsubara Mayflower Hospital, Kato, Japan PubMed articles Google scholar articles
Masahiro Iwamoto Division of Rheumatology and Clinical Immunology, Jichi Medical University, Tochigi, Japan PubMed articles Google scholar articles
Toshiharu Shoji UCB Pharma, Tokyo, Japan PubMed articles Google scholar articles
Osamu Togo UCB Pharma, Tokyo, Japan PubMed articles Google scholar articles
Toshiyuki Okada Astellas Pharma Inc., Tokyo, Japan PubMed articles Google scholar articles
Désirée van der Heijde Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands PubMed articles Google scholar articles
Nobuyuki Miyasaka Department of Rheumatology, Tokyo Medical and Dental University, Tokyo, Japan PubMed articles Google scholar articles
Takao Koike Hokkaido University Graduate School of Medicine, Sapporo, Japan Sapporo Medical Center NTT EC, Sapporo, Hokkaido, Japan PubMed articles Google scholar articles

Correspondence to: Professor Tatsuya Atsumi, Division of Rheumatology, Endocrinology and Nephrology, Graduate School of Medicine, Hokkaido University, North 15, West 7, Kita-ku, Sapporo, Hokkaido 060-8638, Japan; at3tat{at}med.hokudai.ac.jp

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Atsumi T, Tanaka Y, Yamamoto K, et al

Annals of the Rheumatic Diseases 2017;76:1348-1356.

Publication history

Received July 20, 2016
Revised December 7, 2016
Accepted January 1, 2017
First published February 2, 2017.

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July 11, 2017

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Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

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