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We read with deep interest the article by Mathiessen et al 1 aimed to determine whether ultrasound predicts radiographic hand osteoarthritis (OA) progression after 5 years. This prospective study suggested that ultrasound-detected grey-scale synovitis and power Doppler signals were significantly associated with radiographic progression after 5 years. We really appreciate the work conducted by the authors and the findings support the use of ultrasound as a tool to detect patients with hand OA who are likely to progress. However, there are some worthwhile issues that need exploration.
We need to be very careful when assessing the risk factors …
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