Influence of geolocation and ethnicity on the phenotypic expression of primary Sjögren's syndrome at diagnosis in 8310 patients: a cross-sectional study from the Big Data Sjögren Project Consortium

Pilar Brito-Zerón; Nihan Acar-Denizli; Margit Zeher; Astrid Rasmussen; Raphaele Seror; Elke Theander; Xiaomei Li; Chiara Baldini; Jacques-Eric Gottenberg; Debashish Danda; Luca Quartuccio; Roberta Priori; Gabriela Hernandez-Molina; Aike A Kruize; Valeria Valim; Marika Kvarnstrom; Damien Sene; Roberto Gerli; Sonja Praprotnik; David Isenberg; Roser Solans; Maureen Rischmueller; Seung-Ki Kwok; Gunnel Nordmark; Yasunori Suzuki; Roberto Giacomelli; Valerie Devauchelle-Pensec; Michele Bombardieri; Benedikt Hofauer; Hendrika Bootsma; Johan G Brun; Guadalupe Fraile; Steven E Carsons; Tamer A Gheita; Jacques Morel; Cristina Vollenveider; Fabiola Atzeni; Soledad Retamozo; Ildiko Fanny Horvath; Kathy Sivils; Thomas Mandl; Pulukool Sandhya; Salvatore De Vita; Jorge Sanchez-Guerrero; Eefje van der Heijden; Virginia Fernandes Moça Trevisani; Marie Wahren-Herlenius; Xavier Mariette; Manuel Ramos-Casals

doi:10.1136/annrheumdis-2016-209952

Article info

Clinical and epidemiological research

Extended report

Influence of geolocation and ethnicity on the phenotypic expression of primary Sjögren's syndrome at diagnosis in 8310 patients: a cross-sectional study from the Big Data Sjögren Project Consortium

Authors

Pilar Brito-Zerón Autoimmune Diseases Unit, Department of Medicine, Hospital CIMA- Sanitas, Barcelona, Spain Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, IDIBAPS-CELLEX, Department of Autoimmune Diseases, ICMiD, University of Barcelona, Hospital Clínic, Barcelona, Spain PubMed articles Google scholar articles
Nihan Acar-Denizli Department of Statistics, Faculty of Science and Letters, Mimar Sinan Fine Arts University, Istanbul, Turkey PubMed articles Google scholar articles
Margit Zeher Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary PubMed articles Google scholar articles
Astrid Rasmussen Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA PubMed articles Google scholar articles
Raphaele Seror Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique—Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM U1184, Paris, France PubMed articles Google scholar articles
Elke Theander Department of Rheumatology, Malmö University Hospital, Lund University, Lund, Sweden PubMed articles Google scholar articles
Xiaomei Li Department of Rheumatology and Immunology, Anhui Provincial Hospital, Hefei, China PubMed articles Google scholar articles
Chiara Baldini Rheumatology Unit, University of Pisa, Pisa, Italy PubMed articles Google scholar articles
Jacques-Eric Gottenberg Department of Rheumatology, Strasbourg University Hospital, Université de Strasbourg, CNRS, Strasbourg, France PubMed articles Google scholar articles
Debashish Danda Department of Clinical Immunology & Rheumatology, Christian Medical College & Hospital, Vellore, India PubMed articles Google scholar articles
Luca Quartuccio Clinic of Rheumatology, Department of Medical and Biological Sciences, University Hospital “Santa Maria della Misericordia”, Udine, Italy PubMed articles Google scholar articles
Roberta Priori Department of Internal Medicine and Medical Specialties, Rheumatology Clinic, Sapienza University of Rome, Rome, Italy PubMed articles Google scholar articles
Gabriela Hernandez-Molina Immunology and Rheumatology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. México City, Mexico PubMed articles Google scholar articles
Aike A Kruize Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands PubMed articles Google scholar articles
Valeria Valim Department of Medicine, Federal University of Espírito Santo, Vitória, Brazil PubMed articles Google scholar articles
Marika Kvarnstrom Department of Medicine, Solna, Unit of Experimental Rheumatology, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden PubMed articles Google scholar articles
Damien Sene Département de Médecine Interne, Hôpital Lariboisière, Université Paris VII, Assistance Publique-Hôpitaux de Paris, Paris, France PubMed articles Google scholar articles
Roberto Gerli Rheumatology Unit, Department of Medicine, University of Perugia, Perugia, Italy PubMed articles Google scholar articles
Sonja Praprotnik Department of Rheumatology, University Medical Centre, Ljubljana, Slovenia PubMed articles Google scholar articles
David Isenberg Division of Medicine, Centre for Rheumatology, University College London, London, UK PubMed articles Google scholar articles
Roser Solans Department of Internal Medicine, Hospital Vall d'Hebron, Barcelona, Spain PubMed articles Google scholar articles
Maureen Rischmueller Department of Rheumatology, The Queen Elizabeth Hospital, Discipline of Medicine University of Adelaide, South Australia PubMed articles Google scholar articles
Seung-Ki Kwok Division of Rheumatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea PubMed articles Google scholar articles
Gunnel Nordmark Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden PubMed articles Google scholar articles
Yasunori Suzuki Division of Rheumatology, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan PubMed articles Google scholar articles
Roberto Giacomelli Clinical Unit of Rheumatology, School of Medicine, University of l'Aquila, L'Aquila, Italy PubMed articles Google scholar articles
Valerie Devauchelle-Pensec Rheumatology Department, Brest University Hospital, Brest, France PubMed articles Google scholar articles
Michele Bombardieri Centre for Experimental Medicine and Rheumatology, Queen Mary University of London, London, UK PubMed articles Google scholar articles
Benedikt Hofauer Otorhinolaryngology / Head and Neck Surgery, Technical University Munich, Munich, Germany PubMed articles Google scholar articles
Hendrika Bootsma Department of Rheumatology & Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands PubMed articles Google scholar articles
Johan G Brun Department of Clinical Science, University of Bergen; and Department of Rheumatology, Haukeland University Hospital, Bergen, Norway PubMed articles Google scholar articles
Guadalupe Fraile Department of Internal Medicine, Hospital Ramón y Cajal, Madrid, Spain PubMed articles Google scholar articles
Steven E Carsons Division of Rheumatology, Allergy and Immunology Winthrop-University Hospital, Stony Brook University School of Medicine, Mineola, New York, USA PubMed articles Google scholar articles
Tamer A Gheita Rheumatology Department, Kasr Al Ainy School of Medicine, Cairo University, Cairo, Egypt PubMed articles Google scholar articles
Jacques Morel Department of Rheumatology, Teaching hospital and University of Montpellier, Montpellier, France PubMed articles Google scholar articles
Cristina Vollenveider German Hospital, Buenos Aires, Argentina PubMed articles Google scholar articles
Fabiola Atzeni IRCCS Galeazzi Orthopedic Institute, Milan, Italy PubMed articles Google scholar articles
Soledad Retamozo Hospital Privado Universitario de Córdoba, Institute University of Biomedical Sciences University of Córdoba (IUCBC), Cordoba, Argentina PubMed articles Google scholar articles
Ildiko Fanny Horvath Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary PubMed articles Google scholar articles
Kathy Sivils Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA PubMed articles Google scholar articles
Thomas Mandl Department of Rheumatology, Malmö University Hospital, Lund University, Lund, Sweden PubMed articles Google scholar articles
Pulukool Sandhya Department of Clinical Immunology & Rheumatology, Christian Medical College & Hospital, Vellore, India PubMed articles Google scholar articles
Salvatore De Vita Clinic of Rheumatology, Department of Medical and Biological Sciences, University Hospital “Santa Maria della Misericordia”, Udine, Italy PubMed articles Google scholar articles
Jorge Sanchez-Guerrero Immunology and Rheumatology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. México City, Mexico PubMed articles Google scholar articles
Eefje van der Heijden Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands PubMed articles Google scholar articles
Virginia Fernandes Moça Trevisani Federal University of São Paulo, Sao Paulo, Brazil PubMed articles Google scholar articles
Marie Wahren-Herlenius Department of Medicine, Solna, Unit of Experimental Rheumatology, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden PubMed articles Google scholar articles
Xavier Mariette Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique—Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM U1184, Paris, France PubMed articles Google scholar articles
Manuel Ramos-Casals Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, IDIBAPS-CELLEX, Department of Autoimmune Diseases, ICMiD, University of Barcelona, Hospital Clínic, Barcelona, Spain Department of Medicine, University of Barcelona, Barcelona, Spain PubMed articles Google scholar articles

Correspondence to Dr Manuel Ramos-Casals, Servei de Malalties Autoimmunes Sistèmiques, Hospital Clínic, C/Villarroel, 170, Barcelona 08036, Spain; mramos{at}clinic.ub.es

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Citation

Brito-Zerón P, Acar-Denizli N, Zeher M on behalf of the EULAR-SS Task Force Big Data Consortium, et al

Influence of geolocation and ethnicity on the phenotypic expression of primary Sjögren's syndrome at diagnosis in 8310 patients: a cross-sectional study from the Big Data Sjögren Project Consortium

Annals of the Rheumatic Diseases 2017;76:1042-1050.

Publication history

Received May 24, 2016
Revised September 8, 2016
Accepted November 6, 2016
First published November 29, 2016.

Online issue publication

May 13, 2017

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