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We have read with great interest the recent work by Ross et al,1 which provides novel relevant findings about the therapeutic efficacy of using protein phosphatase 2A (PP2A)-activating drugs to target tristetraprolin (TTP) in rheumatoid arthritis (RA). In this elegant work, the authors showed that TTP is overexpressed and colocalises with activated mitogen-activated protein kinase (MAPK) p38 in RA synovial tissue. MAPK p38 phosphorylates and inhibits TTP at two serine residues, and Ross et al determined that these phosphorylation sites are critical for …
Contributors IC and BT wrote the manuscript. JM-G, FR and JG-F helped to draft the manuscript.
Funding This work was supported by PI13/02609 and PI15/00934 grants from ‘Instituto de Salud Carlos III FEDER’. BT is supported by ‘Fundación Conchita Rábago de Jiménez Díaz’.
Competing interests None.
Patient consent Obtained.
Provenance and peer review Not commissioned; internally peer reviewed.
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