GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes

Akiyoshi Nakayama; Hirofumi Nakaoka; Ken Yamamoto; Masayuki Sakiyama; Amara Shaukat; Yu Toyoda; Yukinori Okada; Yoichiro Kamatani; Takahiro Nakamura; Tappei Takada; Katsuhisa Inoue; Tomoya Yasujima; Hiroaki Yuasa; Yuko Shirahama; Hiroshi Nakashima; Seiko Shimizu; Toshihide Higashino; Yusuke Kawamura; Hiraku Ogata; Makoto Kawaguchi; Yasuyuki Ohkawa; Inaho Danjoh; Atsumi Tokumasu; Keiko Ooyama; Toshimitsu Ito; Takaaki Kondo; Kenji Wakai; Blanka Stiburkova; Karel Pavelka; Lisa K Stamp; Nicola Dalbeth; Eurogout Consortium; Yutaka Sakurai; Hiroshi Suzuki; Makoto Hosoyamada; Shin Fujimori; Takashi Yokoo; Tatsuo Hosoya; Ituro Inoue; Atsushi Takahashi; Michiaki Kubo; Hiroshi Ooyama; Toru Shimizu; Kimiyoshi Ichida; Nariyoshi Shinomiya; Tony R Merriman; Hirotaka Matsuo

doi:10.1136/annrheumdis-2016-209632

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Clinical and epidemiological research

Extended report

GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes

Authors

Akiyoshi Nakayama Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan PubMed articles Google scholar articles
Hirofumi Nakaoka Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Mishima, Shizuoka, Japan PubMed articles Google scholar articles
Ken Yamamoto Department of Medical Chemistry, Kurume University School of Medicine, Kurume, Fukuoka, Japan PubMed articles Google scholar articles
Masayuki Sakiyama Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan Department of Dermatology, National Defense Medical College, Tokorozawa, Saitama, Japan PubMed articles Google scholar articles
Amara Shaukat Department of Biochemisty, University of Otago, Dunedin, New Zealand PubMed articles Google scholar articles
Yu Toyoda Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan PubMed articles Google scholar articles
Yukinori Okada Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan PubMed articles Google scholar articles
Yoichiro Kamatani Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan PubMed articles Google scholar articles
Takahiro Nakamura Laboratory for Mathematics, National Defense Medical College, Tokorozawa, Saitama, Japan PubMed articles Google scholar articles
Tappei Takada Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan PubMed articles Google scholar articles
Katsuhisa Inoue Department of Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan PubMed articles Google scholar articles
Tomoya Yasujima Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Aichi, Japan PubMed articles Google scholar articles
Hiroaki Yuasa Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Aichi, Japan PubMed articles Google scholar articles
Yuko Shirahama Department of Medical Chemistry, Kurume University School of Medicine, Kurume, Fukuoka, Japan PubMed articles Google scholar articles
Hiroshi Nakashima Department of Preventive Medicine and Public Health, National Defense Medical College, Tokorozawa, Saitama, Japan PubMed articles Google scholar articles
Seiko Shimizu Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan PubMed articles Google scholar articles
Toshihide Higashino Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan PubMed articles Google scholar articles
Yusuke Kawamura Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan PubMed articles Google scholar articles
Hiraku Ogata Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan PubMed articles Google scholar articles
Makoto Kawaguchi Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan PubMed articles Google scholar articles
Yasuyuki Ohkawa Division of Transcriptomics, Research Center for Transomics Medicine, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan PubMed articles Google scholar articles
Inaho Danjoh Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan PubMed articles Google scholar articles
Atsumi Tokumasu Ryougoku East Gate Clinic, Tokyo, Japan PubMed articles Google scholar articles
Keiko Ooyama Ryougoku East Gate Clinic, Tokyo, Japan PubMed articles Google scholar articles
Toshimitsu Ito Department of Internal Medicine, Self-Defense Forces Central Hospital, Tokyo, Japan PubMed articles Google scholar articles
Takaaki Kondo Program in Radiological and Medical Laboratory Sciences, Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan PubMed articles Google scholar articles
Kenji Wakai Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan PubMed articles Google scholar articles
Blanka Stiburkova First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Institute of Inherited Metabolic Disorders, Prague, Czech Republic Institute of Rheumatology, Prague, Czech Republic PubMed articles Google scholar articles
Karel Pavelka Institute of Rheumatology, Prague, Czech Republic PubMed articles Google scholar articles
Lisa K Stamp Department of Medicine, University of Otago, Christchurch, New Zealand PubMed articles Google scholar articles
Nicola Dalbeth Department of Medicine, University of Auckland, Grafton, Auckland, New Zealand PubMed articles Google scholar articles
Eurogout Consortium
Google scholar articles
Yutaka Sakurai Department of Preventive Medicine and Public Health, National Defense Medical College, Tokorozawa, Saitama, Japan PubMed articles Google scholar articles
Hiroshi Suzuki Department of Pharmacy, The University of Tokyo Hospital, Tokyo, Japan PubMed articles Google scholar articles
Makoto Hosoyamada Department of Human Physiology and Pathology, Faculty of Pharma-Sciences, Teikyo University, Tokyo, Japan PubMed articles Google scholar articles
Shin Fujimori Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan PubMed articles Google scholar articles
Takashi Yokoo Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan PubMed articles Google scholar articles
Tatsuo Hosoya Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan Department of Pathophysiology and Therapy in Chronic Kidney Disease, Jikei University School of Medicine, Tokyo, Japan PubMed articles Google scholar articles
Ituro Inoue Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Mishima, Shizuoka, Japan PubMed articles Google scholar articles
Atsushi Takahashi Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan Omics Research Center, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan PubMed articles Google scholar articles
Michiaki Kubo Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama, Kanagawa, Japan PubMed articles Google scholar articles
Hiroshi Ooyama Ryougoku East Gate Clinic, Tokyo, Japan PubMed articles Google scholar articles
Toru Shimizu Midorigaoka Hospital, Takatsuki, Osaka, Japan Kyoto Industrial Health Association, Kyoto, Japan PubMed articles Google scholar articles
Kimiyoshi Ichida Department of Pathophysiology and Therapy in Chronic Kidney Disease, Jikei University School of Medicine, Tokyo, Japan Department of Pathophysiology, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan PubMed articles Google scholar articles
Nariyoshi Shinomiya Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan PubMed articles Google scholar articles
Tony R Merriman Department of Biochemisty, University of Otago, Dunedin, New Zealand PubMed articles Google scholar articles
Hirotaka Matsuo Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan PubMed articles Google scholar articles

Correspondence to Dr Hirotaka Matsuo, Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan; hmatsuo{at}ndmc.ac.jp

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Citation

Nakayama A, Nakaoka H, Yamamoto K Eurogout Consortium, et al

GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes

Annals of the Rheumatic Diseases 2017;76:869-877.

Publication history

Received March 29, 2016
Revised November 4, 2016
Accepted November 5, 2016
First published November 29, 2016.

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November 02, 2019

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