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Fine-mapping the MHC locus in juvenile idiopathic arthritis (JIA) reveals genetic heterogeneity corresponding to distinct adult inflammatory arthritic diseases

Authors

  • A Hinks Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Science Centre, University Of Manchester, Manchester, UK PubMed articlesGoogle scholar articles
  • J Bowes Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Science Centre, University Of Manchester, Manchester, UK PubMed articlesGoogle scholar articles
  • J Cobb Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Science Centre, University Of Manchester, Manchester, UK NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK PubMed articlesGoogle scholar articles
  • H C Ainsworth Center for Public Health Genomics and Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA PubMed articlesGoogle scholar articles
  • M C Marion Center for Public Health Genomics and Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA PubMed articlesGoogle scholar articles
  • M E Comeau Center for Public Health Genomics and Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA PubMed articlesGoogle scholar articles
  • M Sudman Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • B Han Divisions of Genetics and Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, USA Department of Convergence Medicine, University of Ulsan College of Medicine & Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea PubMed articlesGoogle scholar articles
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  • M L Becker Division of Rheumatology and Division of Clinical Pharmacology, Toxicology, and Therapeutic Innovation, Children's Mercy-Kansas City, Kansas City, Missouri, USA PubMed articlesGoogle scholar articles
  • J F Bohnsack Division of Allergy, Immunology and Paediatric Rheumatology, University of Utah, Salt Lake City, Utah, USA PubMed articlesGoogle scholar articles
  • P I W de Bakker Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands PubMed articlesGoogle scholar articles
  • J P Haas German Center for Pediatric and Adolescent Rheumatology, Garmisch-Partenkirchen, Germany PubMed articlesGoogle scholar articles
  • M Hazen Division of Immunology, Department of Rheumatology, Boston Children's Hospital, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • D J Lovell Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • P A Nigrovic Division of Immunology, Department of Rheumatology, Boston Children's Hospital, Boston, Massachusetts, USA Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA PubMed articlesGoogle scholar articles
  • E Nordal Department of Paediatrics, University Hospital of North Norway, and UIT The Arctic University of Norway, Tromsø, Norway PubMed articlesGoogle scholar articles
  • M Punnaro Arthritis Clinic Texas Scottish Rite Hospital for Children, Dallas, Texas, USA Department of Paediatrics, UT Southwestern Medical Center, Dallas, Texas, USA PubMed articlesGoogle scholar articles
  • A M Rosenberg Division of Rheumatology, Department of Paediatrics, University of Saskatchewan, Saskatoon, Canada PubMed articlesGoogle scholar articles
  • M Rygg Department of Laboratory Medicine, Children's and Women's Health, NTNU - Norwegian University of Science and Technology, and St. Olavs University Hospital, Trondheim, Norway PubMed articlesGoogle scholar articles
  • S L Smith Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Science Centre, University Of Manchester, Manchester, UK PubMed articlesGoogle scholar articles
  • C A Wise Sarah M. and Charles E. Seay Center for Musculoskeletal Research, Texas Scottish Rite Hospital for Children, Dallas, Texas, USA Department of Orthopaedic Surgery, Paediatrics, and McDermott Center for Human Growth and Development, UT Southwestern Medical Center, Dallas, Texas, USA PubMed articlesGoogle scholar articles
  • V Videm Department of Laboratory Medicine, Children's and Women's Health, NTNU - Norwegian University of Science and Technology, and St. Olavs University Hospital, Trondheim, Norway PubMed articlesGoogle scholar articles
  • L R Wedderburn Arthritis Research UK Centre for Adolescent Rheumatology, UCL GOS Institute of Child Health, University College London, London, UK NIHR-Great Ormond Street Hospital Biomedical Research Centre, London, UK PubMed articlesGoogle scholar articles
  • A Yarwood Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Science Centre, University Of Manchester, Manchester, UK PubMed articlesGoogle scholar articles
  • R S M Yeung The Hospital for Sick Children and University of Toronto, Toronto, Canada PubMed articlesGoogle scholar articles
  • S Prahalad Department of Paediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, Atlanta, USA PubMed articlesGoogle scholar articles
  • C D Langefeld Center for Public Health Genomics and Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA PubMed articlesGoogle scholar articles
  • S Raychaudhuri Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Science Centre, University Of Manchester, Manchester, UK Divisions of Genetics and Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, USA Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, USA Department of Medicine, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden PubMed articlesGoogle scholar articles
  • S D Thompson Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • W Thomson Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Science Centre, University Of Manchester, Manchester, UK NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Anne Hinks, Arthritis Research UK Centre for Genetics and Genomics, Manchester Academic Health Science Centre, University Of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK; Anne.Hinks{at}manchester.ac.uk
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Citation

Hinks A, Bowes J, Cobb J, et al
Fine-mapping the MHC locus in juvenile idiopathic arthritis (JIA) reveals genetic heterogeneity corresponding to distinct adult inflammatory arthritic diseases

Publication history

  • Received June 7, 2016
  • Revised September 12, 2016
  • Accepted November 5, 2016
  • First published December 20, 2016.
Online issue publication 
March 10, 2017

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