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Extended report
Endothelial progenitor dysfunction associates with a type I interferon signature in primary antiphospholipid syndrome
  1. Robert C Grenn1,
  2. Srilakshmi Yalavarthi1,
  3. Alex A Gandhi1,
  4. Nayef M Kazzaz1,
  5. Carlos Núñez-Álvarez2,
  6. Diego Hernández-Ramírez2,
  7. Antonio R Cabral2,3,
  8. W Joseph McCune1,
  9. Paula L Bockenstedt4,
  10. Jason S Knight1
  1. 1Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
  2. 2Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
  3. 3Division of Rheumatology, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada
  4. 4Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
  1. Correspondence to Dr Jason S Knight, Division of Rheumatology, University of Michigan, 5520A MSRB1, 1150 W Medical Center Drive, SPC 5680, Ann Arbor, MI 48109-5680, USA; jsknight{at}umich.edu

Footnotes

  • Handling editor Tore K Kvien

  • RCG and SY contributed equally.

  • Twitter Follow Jason Knight at @jasonsknight

  • Contributors RCG, SY, AAG, NMK, CN-A and DH-R conducted experiments and analysed data. ARC, WJM, PLB and JSK analysed data and designed the study. All authors participated in writing the manuscript, and gave approval before submission.

  • Funding JSK was supported by NIH K08AR066569 and a career development award from the Burroughs Wellcome Fund. NMK received funding from the Security Forces Hospital Program, Ministry of Interior, Riyadh, Saudi Arabia. WJM and the Michigan Lupus Cohort were supported by the Mary Piazza Lupus Research Fund and the Michael and Marcia Klein Lupus Research Fund.

  • Competing interests None declared.

  • Ethics approval University Institutional Review Boards.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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Footnotes

  • Handling editor Tore K Kvien

  • RCG and SY contributed equally.

  • Twitter Follow Jason Knight at @jasonsknight

  • Contributors RCG, SY, AAG, NMK, CN-A and DH-R conducted experiments and analysed data. ARC, WJM, PLB and JSK analysed data and designed the study. All authors participated in writing the manuscript, and gave approval before submission.

  • Funding JSK was supported by NIH K08AR066569 and a career development award from the Burroughs Wellcome Fund. NMK received funding from the Security Forces Hospital Program, Ministry of Interior, Riyadh, Saudi Arabia. WJM and the Michigan Lupus Cohort were supported by the Mary Piazza Lupus Research Fund and the Michael and Marcia Klein Lupus Research Fund.

  • Competing interests None declared.

  • Ethics approval University Institutional Review Boards.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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